HCSGD entry for TIGIT
1. General information
| Official gene symbol | TIGIT |
|---|---|
| Entrez ID | 201633 |
| Gene full name | T cell immunoreceptor with Ig and ITIM domains |
| Other gene symbols | VSIG9 VSTM3 WUCAM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0032695 | Negative regulation of interleukin-12 production | IMP | biological_process |
| GO:0032733 | Positive regulation of interleukin-10 production | IMP | biological_process |
| GO:0050868 | Negative regulation of T cell activation | IDA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5172692489 | 0.8095755404 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0851217705 |
| GSE13712_SHEAR | Up | 0.2532225791 |
| GSE13712_STATIC | Down | -0.1900509398 |
| GSE19018 | Down | -0.1217164499 |
| GSE19899_A1 | Up | 0.2413881352 |
| GSE19899_A2 | Down | -0.1472381013 |
| PubMed_21979375_A1 | Up | 0.1280136170 |
| PubMed_21979375_A2 | Down | -0.1595109035 |
| GSE35957 | Up | 0.1467218749 |
| GSE36640 | Up | 0.1540194243 |
| GSE54402 | Down | -0.0061863831 |
| GSE9593 | Down | -0.2710089016 |
| GSE43922 | Up | 0.0163728024 |
| GSE24585 | Up | 0.0185640614 |
| GSE37065 | Down | -0.1142131690 |
| GSE28863_A1 | Up | 0.1886201054 |
| GSE28863_A2 | Up | 0.1900314877 |
| GSE28863_A3 | Up | 0.1444493151 |
| GSE28863_A4 | Up | 0.0694751205 |
| GSE48662 | Up | 0.0071756685 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
