HCSGD entry for HIPK1
1. General information
| Official gene symbol | HIPK1 |
|---|---|
| Entrez ID | 204851 |
| Gene full name | homeodomain interacting protein kinase 1 |
| Other gene symbols | Myak Nbak2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001654 | Eye development | ISS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007224 | Smoothened signaling pathway | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0010803 | Regulation of tumor necrosis factor-mediated signaling pathway | IDA | biological_process |
| GO:0010842 | Retina layer formation | IEA | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0016926 | Protein desumoylation | IDA | biological_process |
| GO:0030182 | Neuron differentiation | IEA | biological_process |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IEA | biological_process |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0045766 | Positive regulation of angiogenesis | ISS | biological_process |
| GO:0048596 | Embryonic camera-type eye morphogenesis | IEA | biological_process |
| GO:0060059 | Embryonic retina morphogenesis in camera-type eye | IEA | biological_process |
| GO:0060216 | Definitive hemopoiesis | ISS | biological_process |
| GO:0060235 | Lens induction in camera-type eye | IEA | biological_process |
| GO:0061072 | Iris morphogenesis | IEA | biological_process |
| GO:0072577 | Endothelial cell apoptotic process | IDA | biological_process |
| GO:0097191 | Extrinsic apoptotic signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0874903119 | 0.8981485202 | 0.6210443635 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0097875842 |
| GSE13712_SHEAR | Up | 0.0200718281 |
| GSE13712_STATIC | Down | -0.0466718796 |
| GSE19018 | Up | 0.1385580912 |
| GSE19899_A1 | Up | 0.2050890948 |
| GSE19899_A2 | Up | 0.0724841159 |
| PubMed_21979375_A1 | Down | -0.0617057531 |
| PubMed_21979375_A2 | Up | 0.0528545416 |
| GSE35957 | Up | 0.3164021258 |
| GSE36640 | Down | -0.0004625721 |
| GSE54402 | Up | 0.5041247642 |
| GSE9593 | Up | 0.1640064935 |
| GSE43922 | Up | 0.2500612436 |
| GSE24585 | Up | 0.2568824980 |
| GSE37065 | Up | 0.0964888670 |
| GSE28863_A1 | Up | 0.1266578752 |
| GSE28863_A2 | Up | 0.7350656372 |
| GSE28863_A3 | Down | -0.5913916635 |
| GSE28863_A4 | Down | -0.3000475777 |
| GSE48662 | Up | 0.2087267138 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-590-3p | MIMAT0004801 | MIRT016192 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029031 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031114 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036950 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040363 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041890 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049450 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051518 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052071 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052695 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
