HCSGD entry for ESR2
1. General information
| Official gene symbol | ESR2 |
|---|---|
| Entrez ID | 2100 |
| Gene full name | estrogen receptor 2 (ER beta) |
| Other gene symbols | ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0001046 | Core promoter sequence-specific DNA binding | IDA | molecular_function |
| GO:0001541 | Ovarian follicle development | IEA | biological_process |
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA TAS | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA TAS | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | NAS | molecular_function |
| GO:0005496 | Steroid binding | IEA ISS TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS | cellular_component |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008628 | Hormone-mediated apoptotic signaling pathway | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010469 | Regulation of receptor activity | NAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030284 | Estrogen receptor activity | TAS | molecular_function |
| GO:0030308 | Negative regulation of cell growth | NAS | biological_process |
| GO:0030520 | Intracellular estrogen receptor signaling pathway | IEA TAS | biological_process |
| GO:0034056 | Estrogen response element binding | IDA | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0048019 | Receptor antagonist activity | NAS | molecular_function |
| GO:0050680 | Negative regulation of epithelial cell proliferation | IEA | biological_process |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0060065 | Uterus development | IEA | biological_process |
| GO:0060068 | Vagina development | IEA | biological_process |
| GO:0060740 | Prostate gland epithelium morphogenesis | IEA | biological_process |
| GO:0060743 | Epithelial cell maturation involved in prostate gland development | IEA | biological_process |
| GO:0060766 | Negative regulation of androgen receptor signaling pathway | IEA | biological_process |
| GO:1900116 | Extracellular negative regulation of signal transduction | NAS | biological_process |
| GO:2000272 | Negative regulation of receptor activity | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2606572509 | 0.9404179628 | 0.9536779956 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0455645271 |
| GSE13712_SHEAR | Down | -0.0661281854 |
| GSE13712_STATIC | Up | 0.0044281590 |
| GSE19018 | Down | -0.0235823166 |
| GSE19899_A1 | Up | 0.0082145906 |
| GSE19899_A2 | Down | -0.0087971725 |
| PubMed_21979375_A1 | Up | 0.0583697131 |
| PubMed_21979375_A2 | Up | 0.0226459295 |
| GSE35957 | Up | 0.0720573196 |
| GSE36640 | Down | -0.2006755177 |
| GSE54402 | Up | 0.6358046046 |
| GSE9593 | Down | -0.0048745738 |
| GSE43922 | Up | 0.0165754296 |
| GSE24585 | Up | 0.8074310218 |
| GSE37065 | Up | 0.0658938556 |
| GSE28863_A1 | Down | -0.0528518707 |
| GSE28863_A2 | Down | -0.0626396563 |
| GSE28863_A3 | Up | 0.2139007780 |
| GSE28863_A4 | Up | 0.0494587171 |
| GSE48662 | Up | 0.3510459560 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT004563 | GFP reporter assay | Functional MTI | 20484043 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017943 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26903639 | The oxytocin receptor gene (OXTR) polymorphism rs53576, which has figured prominently in investigations of social cognition and psychological resources, and the estrogen receptor beta gene (ESR2) polymorphism rs2978381, one of two gonadal sex hormone genes, significantly mitigate the negative effect of impatience on cellular aging in females |
| 23746120 | Furthermore, our results showed that Mig-6 induction of senescence is related to its inhibition of EGF receptor (EGFR)/Erb B signalling |
| 18847333 | Using bone from cycling female rats infused chronically with ethanol (EtOH) in vivo and osteoblastic cells in vitro, we found that EtOH significantly increased estrogen receptor alpha (ERalpha) and beta (ERbeta) mRNA and ERalpha protein levels |
| 18847333 | ERalpha agonist propylpyrazoletriol (PPT) and ERbeta agonist diarylpropionitrile (DPN) attenuated EtOH-induced ERalpha and ERbeta gene overexpression, respectively |
| 16798746 | Raloxifene, like estrogen, clearly induced the telomerase activity and human TERT (hTERT) expression via estrogen receptor (ER) alpha and ERbeta |
| 12135889 | Telomerase-expressing cells contained mRNA for alpha smooth muscle actin, smoothelin, oxytocin receptor, and estrogen receptor alpha, but the estrogen receptor beta receptor was lost |
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