HCSGD entry for ESRRB
1. General information
| Official gene symbol | ESRRB |
|---|---|
| Entrez ID | 2103 |
| Gene full name | estrogen-related receptor beta |
| Other gene symbols | DFNB35 ERR2 ERRb ESRL2 NR3B2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | ISS | molecular_function |
| GO:0001831 | Trophectodermal cellular morphogenesis | IEA | biological_process |
| GO:0001834 | Trophectodermal cell proliferation | IEA | biological_process |
| GO:0001892 | Embryonic placenta development | NAS | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | ISS | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | TAS | molecular_function |
| GO:0005496 | Steroid binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008134 | Transcription factor binding | ISS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0030522 | Intracellular receptor signaling pathway | TAS | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IDA IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6499085407 | 0.8581117625 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0057246993 |
| GSE13712_SHEAR | Up | 0.1215416472 |
| GSE13712_STATIC | Up | 0.0474140280 |
| GSE19018 | Up | 0.0948895138 |
| GSE19899_A1 | Up | 0.0742317468 |
| GSE19899_A2 | Up | 0.0019830211 |
| PubMed_21979375_A1 | Down | -0.1327246466 |
| PubMed_21979375_A2 | Down | -0.0505723195 |
| GSE35957 | Up | 0.0804214282 |
| GSE36640 | Up | 0.0795052919 |
| GSE54402 | Down | -0.0004712938 |
| GSE9593 | Up | 0.0405383079 |
| GSE43922 | Up | 0.0936484876 |
| GSE24585 | Down | -0.0149745011 |
| GSE37065 | Down | -0.0172127762 |
| GSE28863_A1 | Down | -0.1074020514 |
| GSE28863_A2 | Down | -0.0621584776 |
| GSE28863_A3 | Up | 0.2688515008 |
| GSE28863_A4 | Up | 0.1516620532 |
| GSE48662 | Down | -0.1415783379 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017698 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26199639 | RAR-related orphan receptor alpha (RORalpha), an orphan nuclear receptor, is involved in circadian rhythm regulation, including regulation of cardiovascular function |
| 25496115 | ERRbeta splice variants differentially regulate cell cycle progression |
| 25496115 | In this study, we focus on 2 ERRbeta splice variants, short form ERRbeta (ERRbetasf) and ERRbeta2, and identify their differing roles in cell cycle regulation |
| 25496115 | Using DY131 (a synthetic agonist of ERRbeta), splice-variant selective shRNA, and exogenous ERRbetasf and ERRbeta2 cDNAs, we demonstrate the role of ERRbetasf in mediating the G1 checkpoint through p21 |
| 25496115 | In the absence of ERRbeta2, the DY131-induced G2/M arrest is reversed, and this is accompanied by p21 induction and a G1 arrest |
| 25496115 | This study illustrates novel functions for ERRbeta splice variants and provides evidence for splice variant interaction |
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