HCSGD entry for EZH1
1. General information
| Official gene symbol | EZH1 |
|---|---|
| Entrez ID | 2145 |
| Gene full name | enhancer of zeste homolog 1 (Drosophila) |
| Other gene symbols | KMT6B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IEA | molecular_function |
| GO:0035098 | ESC/E(Z) complex | IDA IEA | cellular_component |
| GO:0046976 | Histone methyltransferase activity (H3-K27 specific) | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2154633449 | 0.7903714335 | 0.8935261856 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0324787851 |
| GSE13712_SHEAR | Up | 0.2098669974 |
| GSE13712_STATIC | Down | -0.0095090887 |
| GSE19018 | Up | 0.2217963237 |
| GSE19899_A1 | Down | -0.0515306738 |
| GSE19899_A2 | Up | 0.2077731243 |
| PubMed_21979375_A1 | Down | -0.6242853687 |
| PubMed_21979375_A2 | Up | 0.5321622678 |
| GSE35957 | Up | 0.1310692904 |
| GSE36640 | Up | 0.7590651046 |
| GSE54402 | Down | -0.0082393372 |
| GSE9593 | Up | 0.1914152177 |
| GSE43922 | Down | -0.0956660167 |
| GSE24585 | Down | -0.1842801329 |
| GSE37065 | Down | -0.0573103988 |
| GSE28863_A1 | Up | 0.2379469237 |
| GSE28863_A2 | Up | 0.2241120700 |
| GSE28863_A3 | Down | -0.1520027449 |
| GSE28863_A4 | Down | -0.1573970315 |
| GSE48662 | Up | 0.4975512340 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020281 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028152 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039043 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040210 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-346 | MIMAT0000773 | MIRT042703 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
