HCSGD entry for FABP4
1. General information
| Official gene symbol | FABP4 |
|---|---|
| Entrez ID | 2167 |
| Gene full name | fatty acid binding protein 4, adipocyte |
| Other gene symbols | A-FABP AFABP ALBP aP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001816 | Cytokine production | IEA | biological_process |
| GO:0005215 | Transporter activity | IEA | molecular_function |
| GO:0005504 | Fatty acid binding | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA TAS | cellular_component |
| GO:0005811 | Lipid particle | TAS | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IEA | biological_process |
| GO:0019433 | Triglyceride catabolic process | TAS | biological_process |
| GO:0042632 | Cholesterol homeostasis | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0050729 | Positive regulation of inflammatory response | IEA | biological_process |
| GO:0050872 | White fat cell differentiation | IEA | biological_process |
| GO:0050873 | Brown fat cell differentiation | IEA | biological_process |
| GO:0071285 | Cellular response to lithium ion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9719352684 | 0.0023486494 | 0.9999902473 | 0.0940925419 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1521745143 |
| GSE13712_SHEAR | Down | -2.0454229335 |
| GSE13712_STATIC | Down | -2.9451331978 |
| GSE19018 | Down | -0.1540858195 |
| GSE19899_A1 | Down | -0.3568041874 |
| GSE19899_A2 | Down | -0.1654459882 |
| PubMed_21979375_A1 | Down | -1.8685905139 |
| PubMed_21979375_A2 | Down | -2.0601558754 |
| GSE35957 | Down | -0.0038366561 |
| GSE36640 | Down | -0.3828694054 |
| GSE54402 | Up | 0.0373496740 |
| GSE9593 | Down | -1.4849086963 |
| GSE43922 | Down | -3.0230496733 |
| GSE24585 | Up | 0.2660069243 |
| GSE37065 | Up | 0.0519206102 |
| GSE28863_A1 | Up | 0.0209016608 |
| GSE28863_A2 | Up | 0.0341643336 |
| GSE28863_A3 | Down | -0.0037351186 |
| GSE28863_A4 | Down | -0.0034886140 |
| GSE48662 | Up | 0.0578760930 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-138-5p | MIMAT0000430 | MIRT005490 | qRT-PCR | Functional MTI (Weak) | 20486779 |
| hsa-miR-369-5p | MIMAT0001621 | MIRT005959 | Luciferase reporter assay//Reporter assay | Functional MTI | 21136442 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019040 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21660946 | This was accompanied by respective gene expression changes of some adipogenic key molecules (adiponectin and fatty acid-binding protein 4 [FABP4]) |
| 21660946 | Furthermore luciferase reporter assay indicated that FABP4 is a direct target of miR-369-5p |
| 20374652 | Key markers of adipogenesis including lipoprotein lipase, FABP4, and Itm2a displayed age-dependent declines |
| 17535427 | In undifferentiated senescent cells, PPARG2 and LPL expression is unaltered, whereas LEP and FABP4 transcript levels are increased but not in all clones |
| 17535427 | Bisulfite sequencing analysis of DNA methylation reveals overall relative stability of LEP, PPARG2, FABP4 and LPL promoter CpG methylation during senescence and upon differentiation |
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