HCSGD entry for FANCD2
1. General information
| Official gene symbol | FANCD2 |
|---|---|
| Entrez ID | 2177 |
| Gene full name | Fanconi anemia, complementation group D2 |
| Other gene symbols | FA-D2 FA4 FACD FAD FAD2 FANCD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000793 | Condensed chromosome | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0007129 | Synapsis | IEA | biological_process |
| GO:0007276 | Gamete generation | IEA | biological_process |
| GO:0010332 | Response to gamma radiation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9968667718 | 0.0015769500 | 0.9999902473 | 0.0764399632 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2677995876 |
| GSE13712_SHEAR | Up | 0.0716910693 |
| GSE13712_STATIC | Down | -0.2159432645 |
| GSE19018 | Down | -0.1225644827 |
| GSE19899_A1 | Down | -0.2967515925 |
| GSE19899_A2 | Down | -1.7977057523 |
| PubMed_21979375_A1 | Down | -0.9696922309 |
| PubMed_21979375_A2 | Down | -1.4484997297 |
| GSE35957 | Down | -0.3420414464 |
| GSE36640 | Down | -2.5178725150 |
| GSE54402 | Down | -0.5843437272 |
| GSE9593 | Down | -0.4508873765 |
| GSE43922 | Down | -1.9158423781 |
| GSE24585 | Down | -0.3817839083 |
| GSE37065 | Down | -0.2340905841 |
| GSE28863_A1 | Down | -0.0276101041 |
| GSE28863_A2 | Up | 0.0256151258 |
| GSE28863_A3 | Up | 0.0650887559 |
| GSE28863_A4 | Down | -0.0649801397 |
| GSE48662 | Down | -0.4525373501 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016578 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039141 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041043 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043406 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052045 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7i-5p | MIMAT0000415 | NA | hsa-let-7i | 19939273 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27160904 | We find that a reduced USP1 level causes aberrant aggregation of its target FANCD2 concomitant with replication stress, accumulation, and colocalization of gamma-H2Ax and p53-binding protein 1 (53BP1) in large and unusual sparse DNA damage foci and an increased number of polyploid cells and cells arrested in G2/M, as well as a sensitization of senescence-bypassing cells to DNA interstrand crosslinking-mediated cell death |
| 23806336 | FANCD2 activates transcription of TAp63 and suppresses tumorigenesis |
| 23806336 | A critical step is the monoubiquitination of the FANCD2 protein, and cells from most FA patients are deficient in this step |
| 23806336 | How monoubiquitinated FANCD2 suppresses squamous cell cancers is unknown |
| 21995812 | Checkpoint kinase 1 (Chk1) initiates cell cycle checkpoints, and FANCD2 is known to be involved in DNA damage-induced S-phase arrest and crosslink repair |
| 21995812 | In this study, we examined a role for Chk1 and FANCD2 as downstream effectors of ATR in senescence signalling |
| 21995812 | We demonstrate that Chk1 and FANCD2 are long-lastingly activated after psoralen photoactivation |
| 21995812 | Separate and combined reduction in Chk1 and FANCD2 expression by small interfering RNA (siRNA) preceding irradiation partly prevented the initiation of the senescence-like phenotype, whereas siRNA (Chk1 and FANCD2) transfection of senesced fibroblasts released cells from growth arrest |
| 21995812 | We observed that Chk1 and FANCD2 signal equally and additively for senescence induction, while Chk1 is predominantly responsible for maintaining persistent cell cycle arrest |
| 21995812 | In conclusion, Chk1 and FANCD2 function downstream of ATR in a non-redundant manner for the establishment and maintenance of psoralen photoactivation-induced senescence |
| 19572808 | Expression of FANCD2 and sensitivity to mitomycin C, differentiation capacities, and hematopoiesis-supporting abilities, as well as proliferation, cell senescence, and telomere length were assessed |
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