HCSGD entry for PTK2B

1. General information

Official gene symbolPTK2B
Entrez ID2185
Gene full nameprotein tyrosine kinase 2 beta
Other gene symbolsCADTK CAKB FADK2 FAK2 PKB PTK PYK2 RAFTK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIEAbiological_process
GO:0001556Oocyte maturationIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001954Positive regulation of cell-matrix adhesionIMPbiological_process
GO:0002040Sprouting angiogenesisIEA ISSbiological_process
GO:0002315Marginal zone B cell differentiationIEA ISSbiological_process
GO:0004713Protein tyrosine kinase activityIEA TASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIDA IEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005925Focal adhesionIDA IEAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006461Protein complex assemblyTASbiological_process
GO:0006468Protein phosphorylationTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006950Response to stressTASbiological_process
GO:0006970Response to osmotic stressIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayIMPbiological_process
GO:0007172Signal complex assemblyIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIMPbiological_process
GO:0008284Positive regulation of cell proliferationIEA IMPbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0008360Regulation of cell shapeIEA IMPbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009725Response to hormoneIEAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0010226Response to lithium ionIEAbiological_process
GO:0010595Positive regulation of endothelial cell migrationIDA IEAbiological_process
GO:0010656Negative regulation of muscle cell apoptotic processIEAbiological_process
GO:0010752Regulation of cGMP-mediated signalingIEAbiological_process
GO:0010758Regulation of macrophage chemotaxisIEA ISSbiological_process
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0014009Glial cell proliferationIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0030027LamellipodiumIDAcellular_component
GO:0030155Regulation of cell adhesionIMPbiological_process
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0030424AxonIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0030502Negative regulation of bone mineralizationIEA ISSbiological_process
GO:0030826Regulation of cGMP biosynthetic processIEAbiological_process
GO:0030838Positive regulation of actin filament polymerizationIMPbiological_process
GO:0031175Neuron projection developmentIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032863Activation of Rac GTPase activityIEAbiological_process
GO:0032960Regulation of inositol trisphosphate biosynthetic processIEA ISSbiological_process
GO:0033209Tumor necrosis factor-mediated signaling pathwayIMPbiological_process
GO:0042220Response to cocaineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042976Activation of Janus kinase activityIEA IMPbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043149Stress fiber assemblyIEAbiological_process
GO:0043267Negative regulation of potassium ion transportIDAbiological_process
GO:00434233-phosphoinositide-dependent protein kinase bindingIEAmolecular_function
GO:0043507Positive regulation of JUN kinase activityIEAbiological_process
GO:0043534Blood vessel endothelial cell migrationIEAbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityIEA ISSbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045428Regulation of nitric oxide biosynthetic processIEAbiological_process
GO:0045453Bone resorptionIEA ISSbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045638Negative regulation of myeloid cell differentiationIMPbiological_process
GO:0045727Positive regulation of translationIEAbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0045860Positive regulation of protein kinase activityIMPbiological_process
GO:0046330Positive regulation of JNK cascadeIMPbiological_process
GO:0046777Protein autophosphorylationTASbiological_process
GO:0048010Vascular endothelial growth factor receptor signaling pathwayIEA IMPbiological_process
GO:0048041Focal adhesion assemblyIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIDA IEAcellular_component
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050848Regulation of calcium-mediated signalingIEAbiological_process
GO:0051000Positive regulation of nitric-oxide synthase activityIEAbiological_process
GO:0051279Regulation of release of sequestered calcium ion into cytosolIEA ISSbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0070098Chemokine-mediated signaling pathwayIEA ISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0071300Cellular response to retinoic acidIMPbiological_process
GO:2000058Regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processIDAbiological_process
GO:2000060Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processIEAbiological_process
GO:2000114Regulation of establishment of cell polarityIEA ISSbiological_process
GO:2000249Regulation of actin cytoskeleton reorganizationIEA ISSbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIEAbiological_process
GO:2000538Positive regulation of B cell chemotaxisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67420007220.55569104900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1324590589
GSE13712_SHEARUp0.6097306476
GSE13712_STATICDown-0.0314069064
GSE19018Up0.0338583171
GSE19899_A1Up0.0440893824
GSE19899_A2Up0.0225760529
PubMed_21979375_A1Down-0.3799391522
PubMed_21979375_A2Down-0.2914481212
GSE35957Up0.1280020122
GSE36640Up0.0093691381
GSE54402Up0.0516339883
GSE9593Down-0.0824693181
GSE43922Up0.0157742841
GSE24585Up0.1469839794
GSE37065Down-0.1208222626
GSE28863_A1Up0.0749793931
GSE28863_A2Down-0.0580020231
GSE28863_A3Down-0.1042680765
GSE28863_A4Up0.0434924073
GSE48662Up0.3962201967

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GenisteinDB01645 EXPT01582
4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamideDB08341 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23b-3pMIMAT0000418MIRT006963ImmunoblotFunctional MTI (Weak)22745829
hsa-miR-335-5pMIMAT0000765MIRT018928MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.