HCSGD entry for FGF2
1. General information
| Official gene symbol | FGF2 |
|---|---|
| Entrez ID | 2247 |
| Gene full name | fibroblast growth factor 2 (basic) |
| Other gene symbols | BFGF FGF-2 FGFB HBGF-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | IEA | biological_process |
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0000189 | MAPK import into nucleus | IEA | biological_process |
| GO:0001658 | Branching involved in ureteric bud morphogenesis | IDA | biological_process |
| GO:0001759 | Organ induction | IEA | biological_process |
| GO:0001938 | Positive regulation of endothelial cell proliferation | IMP | biological_process |
| GO:0002042 | Cell migration involved in sprouting angiogenesis | IDA IGI | biological_process |
| GO:0005104 | Fibroblast growth factor receptor binding | IPI | molecular_function |
| GO:0005125 | Cytokine activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006661 | Phosphatidylinositol biosynthetic process | IDA | biological_process |
| GO:0006700 | C21-steroid hormone biosynthetic process | IEA | biological_process |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0008083 | Growth factor activity | IDA | molecular_function |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IGI | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | IDA IGI IPI TAS | biological_process |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0010001 | Glial cell differentiation | IEA | biological_process |
| GO:0010764 | Negative regulation of fibroblast migration | IDA | biological_process |
| GO:0010863 | Positive regulation of phospholipase C activity | IDA | biological_process |
| GO:0017134 | Fibroblast growth factor binding | IEA | molecular_function |
| GO:0021762 | Substantia nigra development | IEA | biological_process |
| GO:0021940 | Positive regulation of cerebellar granule cell precursor proliferation | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030214 | Hyaluronan catabolic process | IDA | biological_process |
| GO:0030308 | Negative regulation of cell growth | IEA | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | IDA | molecular_function |
| GO:0032958 | Inositol phosphate biosynthetic process | IDA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0042056 | Chemoattractant activity | IDA | molecular_function |
| GO:0042060 | Wound healing | TAS | biological_process |
| GO:0042660 | Positive regulation of cell fate specification | IDA | biological_process |
| GO:0043536 | Positive regulation of blood vessel endothelial cell migration | IDA | biological_process |
| GO:0043537 | Negative regulation of blood vessel endothelial cell migration | IDA | biological_process |
| GO:0043552 | Positive regulation of phosphatidylinositol 3-kinase activity | IDA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045669 | Positive regulation of osteoblast differentiation | IEA | biological_process |
| GO:0045765 | Regulation of angiogenesis | TAS | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046668 | Regulation of retinal cell programmed cell death | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0048598 | Embryonic morphogenesis | TAS | biological_process |
| GO:0048678 | Response to axon injury | IEA | biological_process |
| GO:0048864 | Stem cell development | IEA | biological_process |
| GO:0050918 | Positive chemotaxis | IDA | biological_process |
| GO:0051209 | Release of sequestered calcium ion into cytosol | IDA | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
| GO:0051781 | Positive regulation of cell division | IEA | biological_process |
| GO:0060045 | Positive regulation of cardiac muscle cell proliferation | IDA | biological_process |
| GO:0060128 | Corticotropin hormone secreting cell differentiation | IEA | biological_process |
| GO:0060129 | Thyroid-stimulating hormone-secreting cell differentiation | IEA | biological_process |
| GO:0060548 | Negative regulation of cell death | IDA | biological_process |
| GO:0060591 | Chondroblast differentiation | IDA | biological_process |
| GO:0060644 | Mammary gland epithelial cell differentiation | IEA | biological_process |
| GO:0061045 | Negative regulation of wound healing | IDA | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0057672771 | 0.0719958056 | 0.1985117647 | 0.5051990403 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5276731853 |
| GSE13712_SHEAR | Down | -0.5074844018 |
| GSE13712_STATIC | Down | -0.3138859263 |
| GSE19018 | Down | -0.3005668648 |
| GSE19899_A1 | Up | 1.7015908483 |
| GSE19899_A2 | Up | 1.9263823805 |
| PubMed_21979375_A1 | Up | 2.3996026185 |
| PubMed_21979375_A2 | Up | 1.2079855004 |
| GSE35957 | Up | 1.0873862239 |
| GSE36640 | Up | 1.5427123674 |
| GSE54402 | Up | 1.0790518684 |
| GSE9593 | Up | 0.0763436623 |
| GSE43922 | Up | 0.4723252448 |
| GSE24585 | Down | -0.2439304910 |
| GSE37065 | Up | 0.1926731692 |
| GSE28863_A1 | Down | -0.8559159525 |
| GSE28863_A2 | Down | -0.1970433106 |
| GSE28863_A3 | Down | -0.3500879999 |
| GSE28863_A4 | Down | -0.4905115465 |
| GSE48662 | Up | 0.1731340644 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Sucralfate | DB00364 | APRD01238 |
| Pentosan Polysulfate | DB00686 | APRD01175 |
| Sirolimus | DB00877 | APRD00178 | DB02439 |
| 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid | DB03935 | EXPT01845 |
| N,O6-Disulfo-Glucosamine | DB03959 | EXPT02898 |
| 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid | DB03981 | EXPT03166 |
| ABT-510 | DB05434 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001468 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001468 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-140-5p | MIMAT0000431 | MIRT003962 | Microarray | Functional MTI (Weak) | 17875710 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT007223 | Luciferase reporter assay | Functional MTI | 23352645 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020683 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021161 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024732 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026446 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027141 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028310 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049684 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 13 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26675707 | We found that platelet-derived growth factor BB in mESC-CM plays a critical role in antisenescence effect of mESC-CM through up-regulation of fibroblast growth factor 2 |
| 26568417 | We also demonstrate that oxidative stress promoted the expression of Btg2, and that FGF2 and IGF1 which are survival signals for embryonic limb mesenchyme inhibited Btg2 expression |
| 25815136 | Secreted tumor growth factor-beta and fibroblast growth factor-2 are reported to play a role in stem cell quiescence |
| 25375819 | The influence of the culture media alpha-MEM, low-glucose DMEM, and high-glucose DMEM, used in cell isolation and expansion, was investigated in the presence and absence of basic fibroblast growth factor (bFGF) |
| 20627123 | Dynamic SUMO regulation controls the biological outcomes initiated by various growth factors involved in cartilage homeostasis, including basic fibroblast growth factors (bFGF or FGF-2), transforming growth factor-beta (TGF-beta) and insulin-like growth factor-1 (IGF-1) |
| 19433493 | PTTG1 induces fibroblast growth factor 2 expression and promotes tumor angiogenesis |
| 19085240 | Proliferation, cell viability, mineralization assays, and mRNA levels were assessed for type I and III collagen, platelet-derived growth factor (PDGF)-1, basic fibroblast growth factor (bFGF), metalloproteinase (MMP)-2 and-8, and tissue inhibitor of metalloproteinases (TIMP)-1 and-2 |
| 16755088 | Angiogenic growth factors secreted by EPCs, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), hepatocyte growth factor (HGF), and macrophage chemoattractant protein (MCP-1) from the culture medium were also measured by enzyme-linked immunosorbent assay |
| 16609829 | In this study, venous ulcer fibroblasts are examined for cell cycle protein expression and modulation by basic fibroblast growth factor (bFGF) |
| 16280018 | RESULTS: There was no correlation between age and hepatocyte growth factor (HGF), stem cell factor (SCF), and basic fibroblast growth factor (bFGF) secretion by fibroblasts |
| 12704538 | Basic fibroblast growth factor (bFGF) has been shown to improve growth rates in these fibroblasts |
| 12676798 | In this study, we examined the relationship between telomerase activity and endothelial cell proliferation as well as the regulation of this enzyme by fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor-A (VEGF) |
| 1716619 | The authors tried to determine whether human corneal endothelial cells in primary culture synthesize messenger RNA (mRNA) coding for epidermal growth factor (EGF), EGF receptor, basic fibroblast growth factor (FGFb), transforming growth factor beta-1 (TGFb1), and interleukin-1 alpha (IL-1 alpha) |
| 1716619 | The polymerase chain reaction (PCR) was used to amplify the growth factors (EGF, FGFb, TGFb1, and IL-1 alpha), EGF receptor, and beta actin sequences from each of the cDNA samples |
| 1716619 | The EGF receptor, FGFb, and beta actin mRNAs were present in all eight cDNA samples |
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