HCSGD entry for FGF8

1. General information

Official gene symbolFGF8
Entrez ID2253
Gene full namefibroblast growth factor 8 (androgen-induced)
Other gene symbolsAIGF FGF-8 HBGF-8 HH6 KAL6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIEAbiological_process
GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001656Metanephros developmentIEPbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0001759Organ inductionIEAbiological_process
GO:0001823Mesonephros developmentIEPbiological_process
GO:0001839Neural plate morphogenesisIEAbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0003148Outflow tract septum morphogenesisISSbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationISSbiological_process
GO:0005104Fibroblast growth factor receptor bindingIEAmolecular_function
GO:0005105Type 1 fibroblast growth factor receptor bindingIDAmolecular_function
GO:0005111Type 2 fibroblast growth factor receptor bindingIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0006979Response to oxidative stressIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007369GastrulationNASbiological_process
GO:0008045Motor neuron axon guidanceIEAbiological_process
GO:0008078Mesodermal cell migrationIEAbiological_process
GO:0008083Growth factor activityIDA IEAmolecular_function
GO:0008284Positive regulation of cell proliferationIDA IEAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008406Gonad developmentIMPbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIGI TASbiological_process
GO:0009653Anatomical structure morphogenesisNASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0021543Pallium developmentIEAbiological_process
GO:0021544Subpallium developmentIEAbiological_process
GO:0021798Forebrain dorsal/ventral pattern formationIEAbiological_process
GO:0021846Cell proliferation in forebrainIEAbiological_process
GO:0021884Forebrain neuron developmentIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0030539Male genitalia developmentIEAbiological_process
GO:0030878Thyroid gland developmentIEAbiological_process
GO:0030916Otic vesicle formationIEAbiological_process
GO:0030917Midbrain-hindbrain boundary developmentIEAbiological_process
GO:0033563Dorsal/ventral axon guidanceIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035909Aorta morphogenesisIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042056Chemoattractant activityIEAmolecular_function
GO:0042476OdontogenesisIEPbiological_process
GO:0042487Regulation of odontogenesis of dentin-containing toothIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045840Positive regulation of mitosisIEAbiological_process
GO:0046622Positive regulation of organ growthIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048853Forebrain morphogenesisIEAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0055026Negative regulation of cardiac muscle tissue developmentIMPbiological_process
GO:0060037Pharyngeal system developmentIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0060128Corticotropin hormone secreting cell differentiationIEAbiological_process
GO:0060129Thyroid-stimulating hormone-secreting cell differentiationIEAbiological_process
GO:0060348Bone developmentIMPbiological_process
GO:0060425Lung morphogenesisIEAbiological_process
GO:0060445Branching involved in salivary gland morphogenesisIEAbiological_process
GO:0060563Neuroepithelial cell differentiationIDAbiological_process
GO:0071542Dopaminergic neuron differentiationIDAbiological_process
GO:0090134Cell migration involved in mesendoderm migrationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24388615930.88694006690.93205351341.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1270005477
GSE13712_SHEARDown-0.1269243355
GSE13712_STATICUp0.2754737337
GSE19018Up0.2218514366
GSE19899_A1Up0.0101244447
GSE19899_A2Down-0.0819290411
PubMed_21979375_A1Down-0.1551653984
PubMed_21979375_A2Up0.2080375184
GSE35957Up0.1579041097
GSE36640Up0.0883789141
GSE54402Down-0.0577248226
GSE9593Down-0.0059171091
GSE43922Up0.1356189043
GSE24585Down-0.0149909450
GSE37065Down-0.0356769530
GSE28863_A1Down-0.0194823571
GSE28863_A2Up0.0457716067
GSE28863_A3Up0.6753752024
GSE28863_A4Up0.0394291813
GSE48662Down-0.0453187680

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017212MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.