HCSGD entry for DIS3
1. General information
| Official gene symbol | DIS3 |
|---|---|
| Entrez ID | 22894 |
| Gene full name | DIS3 mitotic control homolog (S. cerevisiae) |
| Other gene symbols | EXOSC11 KIAA1008 RP11-342J4.3 RRP44 bA555G22.1 dis3p |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000175 | 3'-5'-exoribonuclease activity | IMP | molecular_function |
| GO:0000176 | Nuclear exosome (RNase complex) | IDA | cellular_component |
| GO:0000178 | Exosome (RNase complex) | TAS | cellular_component |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004519 | Endonuclease activity | IMP | molecular_function |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006364 | RRNA processing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016075 | RRNA catabolic process | IMP | biological_process |
| GO:0043087 | Regulation of GTPase activity | IDA | biological_process |
| GO:0043928 | Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | TAS | biological_process |
| GO:0071034 | CUT catabolic process | IMP | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IMP | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | IMP | biological_process |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0273898674 | 0.9340001672 | 0.3838810969 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0925522677 |
| GSE13712_SHEAR | Up | 0.4472472492 |
| GSE13712_STATIC | Up | 0.4164130602 |
| GSE19018 | Down | -0.1767630091 |
| GSE19899_A1 | Up | 0.6816330827 |
| GSE19899_A2 | Up | 0.2267318828 |
| PubMed_21979375_A1 | Up | 0.6833184927 |
| PubMed_21979375_A2 | Up | 0.2610246877 |
| GSE35957 | Up | 0.2242984793 |
| GSE36640 | Down | -0.3458173829 |
| GSE54402 | Up | 0.3545016102 |
| GSE9593 | Down | -0.1419973614 |
| GSE43922 | Up | 0.1977891584 |
| GSE24585 | Down | -0.0587141043 |
| GSE37065 | Up | 0.0254970304 |
| GSE28863_A1 | Up | 0.8739050756 |
| GSE28863_A2 | Up | 0.4264178850 |
| GSE28863_A3 | Down | -0.6544027357 |
| GSE28863_A4 | Up | 0.1856176188 |
| GSE48662 | Down | -0.1376767032 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022253 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028852 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047998 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
