HCSGD entry for FOXC1

1. General information

Official gene symbolFOXC1
Entrez ID2296
Gene full nameforkhead box C1
Other gene symbolsARA FKHL7 FREAC-3 FREAC3 IGDA IHG1 IRID1 RIEG3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0001501Skeletal system developmentIEAbiological_process
GO:0001503OssificationIEAbiological_process
GO:0001541Ovarian follicle developmentIEAbiological_process
GO:0001654Eye developmentIDAbiological_process
GO:0001657Ureteric bud developmentIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0001945Lymph vessel developmentIEAbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003690Double-stranded DNA bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0005720Nuclear heterochromatinIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIBAbiological_process
GO:0007219Notch signaling pathwayIBAbiological_process
GO:0007389Pattern specification processIBAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007507Heart developmentIDAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008301DNA binding, bendingIDAmolecular_function
GO:0008354Germ cell migrationIEAbiological_process
GO:0009790Embryo developmentIBAbiological_process
GO:0009888Tissue developmentIBAbiological_process
GO:0014032Neural crest cell developmentIEAbiological_process
GO:0030199Collagen fibril organizationIEAbiological_process
GO:0030203Glycosaminoglycan metabolic processIEAbiological_process
GO:0031490Chromatin DNA bindingIBAmolecular_function
GO:0032808Lacrimal gland developmentIEAbiological_process
GO:0035050Embryonic heart tube developmentIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIMPbiological_process
GO:0043010Camera-type eye developmentIEAbiological_process
GO:0043066Negative regulation of apoptotic processIBAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDA NASbiological_process
GO:0045930Negative regulation of mitotic cell cycleIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA ISSbiological_process
GO:0046620Regulation of organ growthIBAbiological_process
GO:0048010Vascular endothelial growth factor receptor signaling pathwayIBAbiological_process
GO:0048341Paraxial mesoderm formationIEAbiological_process
GO:0048844Artery morphogenesisIEAbiological_process
GO:0050880Regulation of blood vessel sizeIEAbiological_process
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityIBAbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisIEAbiological_process
GO:0060038Cardiac muscle cell proliferationIEAbiological_process
GO:1902257Negative regulation of apoptotic process involved in outflow tract morphogenesisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10828402040.15569335130.68266914970.7624194791

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1115430564
GSE13712_SHEARDown-1.1050302830
GSE13712_STATICDown-1.6773795418
GSE19018Down-0.1135879415
GSE19899_A1Down-0.2966871809
GSE19899_A2Down-0.1393837180
PubMed_21979375_A1Up0.5475021254
PubMed_21979375_A2Up0.3650053420
GSE35957Down-1.1706715444
GSE36640Up0.9911717997
GSE54402Up0.3778181123
GSE9593Up0.0734881607
GSE43922Up0.0079998557
GSE24585Up0.8625265505
GSE37065Up0.1563912347
GSE28863_A1Down-0.0500462541
GSE28863_A2Up0.2219714213
GSE28863_A3Up0.3029053640
GSE28863_A4Down-0.2556856040
GSE48662Up0.3718811384

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-204-5pMIMAT0000265MIRT006344Luciferase reporter assay//Western blot//Reporter assayFunctional MTI21400511
hsa-miR-1236-3pMIMAT0005591MIRT036256CLASHFunctional MTI (Weak)23622248
hsa-miR-940MIMAT0004983MIRT036606CLASHFunctional MTI (Weak)23622248
hsa-miR-877-5pMIMAT0004949MIRT037280CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041194CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043069CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-3pMIMAT0000732MIRT043933CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.