HCSGD entry for TAB2

1. General information

Official gene symbolTAB2
Entrez ID23118
Gene full nameTGF-beta activated kinase 1/MAP3K7 binding protein 2
Other gene symbolsCHTD2 MAP3K7IP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0007507Heart developmentIMPbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010008Endosome membraneTAScellular_component
GO:0016301Kinase activityIEAmolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0070530K63-linked polyubiquitin bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51834681810.79861249190.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1267843892
GSE13712_SHEARUp0.1481254468
GSE13712_STATICUp0.0520704355
GSE19018Up0.0690151601
GSE19899_A1Up0.1706984466
GSE19899_A2Down-0.0226617762
PubMed_21979375_A1Up0.1197001721
PubMed_21979375_A2Down-0.1079111059
GSE35957Down-0.0391068205
GSE36640Up0.0349001293
GSE54402Up0.1964481287
GSE9593Up0.1324951431
GSE43922Down-0.0425552476
GSE24585Down-0.1385569176
GSE37065Up0.1003045130
GSE28863_A1Up0.1230453266
GSE28863_A2Up0.2184489732
GSE28863_A3Up0.0357598810
GSE28863_A4Down-0.2422024223
GSE48662Up0.4059369375

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT000289Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI19193853
hsa-miR-155-5pMIMAT0000646MIRT000289Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20852130
hsa-miR-155-5pMIMAT0000646MIRT000289Luciferase reporter assayFunctional MTI23449975
hsa-miR-155-5pMIMAT0000646MIRT000289Reporter assayFunctional MTI20680360
hsa-miR-155-5pMIMAT0000646MIRT000289Reporter assay;OtherNon-Functional MTI20584899
hsa-let-7b-5pMIMAT0000063MIRT005057MicroarrayFunctional MTI (Weak)17699775
hsa-let-7b-5pMIMAT0000063MIRT005057CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT007040Luciferase reporter assayFunctional MTI22660635
hsa-miR-181a-5pMIMAT0000256MIRT025198SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027769MicroarrayFunctional MTI (Weak)19088304
hsa-miR-15b-5pMIMAT0000417MIRT046408CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048189CLASHFunctional MTI (Weak)23622248
hsa-let-7f-5pMIMAT0000067MIRT051388CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052592CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT0000646NAhsa-miR-15519193853
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.