HCSGD entry for ARHGEF18
1. General information
| Official gene symbol | ARHGEF18 |
|---|---|
| Entrez ID | 23370 |
| Gene full name | Rho/Rac guanine nucleotide exchange factor (GEF) 18 |
| Other gene symbols | P114-RhoGEF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IDA TAS | biological_process |
| GO:0008360 | Regulation of cell shape | IDA | biological_process |
| GO:0030036 | Actin cytoskeleton organization | IDA | biological_process |
| GO:0030054 | Cell junction | TAS | cellular_component |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0043087 | Regulation of GTPase activity | IDA | biological_process |
| GO:0045177 | Apical part of cell | IDA | cellular_component |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1881397249 | 0.7026216709 | 0.8451998123 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3031953443 |
| GSE13712_SHEAR | Up | 0.4715419738 |
| GSE13712_STATIC | Up | 0.3514547622 |
| GSE19018 | Down | -0.2324343207 |
| GSE19899_A1 | Down | -0.5941286922 |
| GSE19899_A2 | Up | 0.3905611051 |
| PubMed_21979375_A1 | Down | -0.2411817716 |
| PubMed_21979375_A2 | Up | 0.6975636547 |
| GSE35957 | Down | -0.3588728122 |
| GSE36640 | Down | -0.0911324274 |
| GSE54402 | Down | -0.1029865880 |
| GSE9593 | Up | 0.1645995160 |
| GSE43922 | Up | 0.0479092967 |
| GSE24585 | Up | 0.1171817053 |
| GSE37065 | Down | -0.1401672741 |
| GSE28863_A1 | Up | 0.0208478713 |
| GSE28863_A2 | Up | 0.2273048764 |
| GSE28863_A3 | Up | 0.0941211998 |
| GSE28863_A4 | Down | -0.0201745394 |
| GSE48662 | Up | 0.3209938885 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002801 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002801 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030443 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046963 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
