HCSGD entry for FOLR1
1. General information
| Official gene symbol | FOLR1 |
|---|---|
| Entrez ID | 2348 |
| Gene full name | folate receptor 1 (adult) |
| Other gene symbols | FBP FOLR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005542 | Folic acid binding | IDA NAS | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005768 | Endosome | IEA | cellular_component |
| GO:0005886 | Plasma membrane | NAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006898 | Receptor-mediated endocytosis | TAS | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008517 | Folic acid transporter activity | IMP | molecular_function |
| GO:0015884 | Folic acid transport | IMP | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0030136 | Clathrin-coated vesicle | IEA | cellular_component |
| GO:0031362 | Anchored component of external side of plasma membrane | IDA | cellular_component |
| GO:0031526 | Brush border membrane | IEA | cellular_component |
| GO:0046655 | Folic acid metabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2602165647 | 0.6732562479 | 0.9532299624 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0580069893 |
| GSE13712_SHEAR | Down | -0.0456033304 |
| GSE13712_STATIC | Down | -0.1540868160 |
| GSE19018 | Up | 0.0688203347 |
| GSE19899_A1 | Up | 0.0880368698 |
| GSE19899_A2 | Up | 0.0520655167 |
| PubMed_21979375_A1 | Down | -0.6822567973 |
| PubMed_21979375_A2 | Down | -0.3254908908 |
| GSE35957 | Up | 0.5209653357 |
| GSE36640 | Up | 0.0988531298 |
| GSE54402 | Down | -0.0007353326 |
| GSE9593 | Up | 0.2468047685 |
| GSE43922 | Up | 0.0168543487 |
| GSE24585 | Up | 0.3008540256 |
| GSE37065 | Up | 0.1192527339 |
| GSE28863_A1 | Down | -0.0346325442 |
| GSE28863_A2 | Down | -0.1276284436 |
| GSE28863_A3 | Up | 0.1847606859 |
| GSE28863_A4 | Up | 0.1588822714 |
| GSE48662 | Up | 0.5320800203 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019895 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-1 | MIMAT0000416 | MIRT023991 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 3624486 | Since this difference was not reflected in proportionately higher immunoreactive folate binding protein, (as determined by a specific radioimmunoassay for these proteins), or differences in affinity in younger than aged cells, these findings indicate that erythrocyte folate binding proteins become progressively nonfunctional at the onset of red cell aging |
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