HCSGD entry for PHLDA3
1. General information
| Official gene symbol | PHLDA3 |
|---|---|
| Entrez ID | 23612 |
| Gene full name | pleckstrin homology-like domain, family A, member 3 |
| Other gene symbols | TIH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | IDA | molecular_function |
| GO:0005547 | Phosphatidylinositol-3,4,5-trisphosphate binding | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0010314 | Phosphatidylinositol-5-phosphate binding | IDA | molecular_function |
| GO:0032266 | Phosphatidylinositol-3-phosphate binding | IDA | molecular_function |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IDA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0043325 | Phosphatidylinositol-3,4-bisphosphate binding | IDA | molecular_function |
| GO:0051898 | Negative regulation of protein kinase B signaling | IDA | biological_process |
| GO:0080025 | Phosphatidylinositol-3,5-bisphosphate binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0828731431 | 0.6420679723 | 0.6070267112 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2829761005 |
| GSE13712_SHEAR | Down | -0.4116593869 |
| GSE13712_STATIC | Up | 0.5971870303 |
| GSE19018 | Down | -0.0211418916 |
| GSE19899_A1 | Up | 0.0199864928 |
| GSE19899_A2 | Up | 0.3364871078 |
| PubMed_21979375_A1 | Up | 0.3109858739 |
| PubMed_21979375_A2 | Up | 0.6167510407 |
| GSE35957 | Up | 0.6674967830 |
| GSE36640 | Up | 0.5615918407 |
| GSE54402 | Down | -0.6188251555 |
| GSE9593 | Up | 0.4039013054 |
| GSE43922 | Down | -0.0081056634 |
| GSE24585 | Up | 0.1504862651 |
| GSE37065 | Up | 0.0305672788 |
| GSE28863_A1 | Down | -0.2320700293 |
| GSE28863_A2 | Down | -0.1026345389 |
| GSE28863_A3 | Down | -0.2954184196 |
| GSE28863_A4 | Down | -0.1816596139 |
| GSE48662 | Up | 0.8026333789 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-769-3p | MIMAT0003887 | MIRT039099 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
