HCSGD entry for BACE1
1. General information
| Official gene symbol | BACE1 |
|---|---|
| Entrez ID | 23621 |
| Gene full name | beta-site APP-cleaving enzyme 1 |
| Other gene symbols | ASP2 BACE HSPC104 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004190 | Aspartic-type endopeptidase activity | IDA IEA | molecular_function |
| GO:0005768 | Endosome | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005802 | Trans-Golgi network | IDA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0006508 | Proteolysis | IDA IEA | biological_process |
| GO:0006509 | Membrane protein ectodomain proteolysis | TAS | biological_process |
| GO:0008798 | Beta-aspartyl-peptidase activity | TAS | molecular_function |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0030659 | Cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0050435 | Beta-amyloid metabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4534484784 | 0.0163838570 | 0.9999902473 | 0.2497044007 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4138364206 |
| GSE13712_SHEAR | Up | 0.0051912601 |
| GSE13712_STATIC | Down | -0.2133760066 |
| GSE19018 | Down | -0.2939318347 |
| GSE19899_A1 | Down | -0.7037847365 |
| GSE19899_A2 | Down | -1.5113427811 |
| PubMed_21979375_A1 | Down | -2.1189205970 |
| PubMed_21979375_A2 | Down | -0.7617970444 |
| GSE35957 | Up | 0.1071848124 |
| GSE36640 | Up | 0.4003171610 |
| GSE54402 | Down | -0.7987786410 |
| GSE9593 | Up | 0.0090313198 |
| GSE43922 | Down | -0.5296988248 |
| GSE24585 | Up | 0.2963472204 |
| GSE37065 | Down | -0.1977179920 |
| GSE28863_A1 | Up | 0.7238242176 |
| GSE28863_A2 | Up | 0.7550315299 |
| GSE28863_A3 | Down | -0.1568123135 |
| GSE28863_A4 | Up | 0.1047839267 |
| GSE48662 | Up | 0.2567551431 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| MMI-175 | DB02378 | EXPT02196 |
| CTS-21166 | DB06073 | - |
| N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide | DB06930 | - |
| N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE | DB07019 | - |
| N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide | DB07089 | - |
| 4-(4-FLUOROBENZYL)PIPERIDINE | DB07110 | - |
| N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide | DB07175 | - |
| 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE | DB07206 | - |
| 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE | DB07245 | - |
| N~3~-BENZYLPYRIDINE-2,3-DIAMINE | DB07281 | - |
| N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE | DB07284 | - |
| N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE | DB07303 | - |
| 4-(2-aminoethyl)-2-cyclohexylphenol | DB07345 | - |
| 4-(2-aminoethyl)-2-ethylphenol | DB07346 | - |
| 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine | DB07415 | - |
| (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one | DB07519 | - |
| 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one | DB07535 | - |
| (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol | DB07573 | - |
| N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide | DB07734 | - |
| N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide | DB07735 | - |
| (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide | DB07736 | - |
| (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide | DB07737 | - |
| N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide | DB07738 | - |
| (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one | DB07874 | - |
| N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE | DB07993 | - |
| N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE | DB07994 | - |
| 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE | DB08749 | - |
| MK-8931 | DB08929 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-328-3p | MIMAT0000752 | MIRT000080 | Luciferase reporter assay | Functional MTI | 18716028 |
| hsa-miR-298 | MIMAT0004901 | MIRT000103 | Luciferase reporter assay | Functional MTI | 18642050 |
| hsa-miR-107 | MIMAT0000104 | MIRT000800 | Western blot//Northern blot//Luciferase reporter assay//Reporter assay | Functional MTI | 18234899 |
| hsa-miR-107 | MIMAT0000104 | MIRT000800 | Western blot;Microarray | Functional MTI | 20489155 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT000930 | Luciferase reporter assay//Western blot | Functional MTI | 18434550 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT001736 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 18434550 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT001766 | Luciferase reporter assay//Western blot//Reporter assay;Other | Functional MTI | 18434550 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT001793 | Luciferase reporter assay//Reporter assay;Other | Non-Functional MTI | 18434550 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT001802 | Luciferase reporter assay//Reporter assay;Other | Non-Functional MTI | 18434550 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT001825 | Luciferase reporter assay | Non-Functional MTI | 18434550 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT020416 | Reporter assay;Western blot;qRT-PCR | Functional MTI | 21565331 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030156 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050944 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-107 | MIMAT0000104 | 1 | hsa-miR-107 | 18234899 | |||
| hsa-miR-29a-3p | MIMAT0000086 | 1 | hsa-miR-29a | {Western blot} | {overexpression by mature miRNA transfection} | 18434550 | |
| hsa-miR-29b-3p | MIMAT0000100 | 1 | hsa-miR-29b | {Western blot} | {overexpression by mature miRNA transfection} | 18434550 | |
| hsa-miR-9-5p | MIMAT0000441 | NA | hsa-miR-9 | 18434550 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20127045 | Here we show that the protein-protein interaction of amyloid precursor protein (APP) and beta -site amyloid cleavage enzyme 1 (BACE1) is enhanced by the fluorescence resonance energy transfer (FRET) assay during the aging process, and the APP-BACE1 complex accumulates in the endosome in the IMR-90 fibroblast (NHF) cellular aging models |
| 16303768 | ADAM10 (a disintegrin and metalloprotease 10) and BACE (beta-site APP-cleaving enzyme) protein levels exhibited no age-associated regulation, but interestingly, BACE enzymatic activity was increased in aged cells |
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