HCSGD entry for CBLC

1. General information

Official gene symbolCBLC
Entrez ID23624
Gene full nameCbl proto-oncogene, E3 ubiquitin protein ligase C
Other gene symbolsCBL-3 CBL-SL RNF57
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001784Phosphotyrosine bindingIDAmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005154Epidermal growth factor receptor bindingIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0007166Cell surface receptor signaling pathwayIEAbiological_process
GO:0007175Negative regulation of epidermal growth factor-activated receptor activityIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayIDAbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86026245580.74645303370.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0034754671
GSE13712_SHEARDown-0.0489015742
GSE13712_STATICUp0.0419606118
GSE19018Up0.0271160452
GSE19899_A1Down-0.0618417334
GSE19899_A2Up0.0939539153
PubMed_21979375_A1Up0.0352240229
PubMed_21979375_A2Down-0.1051853068
GSE35957Up0.0974870179
GSE36640Up0.1465161661
GSE54402Up0.0230601321
GSE9593Down-0.0204311785
GSE43922Up0.0309716767
GSE24585Down-0.0509039056
GSE37065Down-0.1697881313
GSE28863_A1Down-0.0939489184
GSE28863_A2Down-0.0747686687
GSE28863_A3Up0.2813742945
GSE28863_A4Up0.0250725416
GSE48662Up0.0011050178

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029439MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.