HCSGD entry for SPO11

1. General information

Official gene symbolSPO11
Entrez ID23626
Gene full nameSPO11 meiotic protein covalently bound to DSB
Other gene symbolsCT35 SPATA43 TOPVIA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000781Chromosome, telomeric regionIEAcellular_component
GO:0001541Ovarian follicle developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003824Catalytic activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005694ChromosomeIEAcellular_component
GO:0006259DNA metabolic processIEAbiological_process
GO:0007129SynapsisIEAbiological_process
GO:0007131Reciprocal meiotic recombinationIEAbiological_process
GO:0007141Male meiosis IIEAbiological_process
GO:0007283SpermatogenesisTASbiological_process
GO:0007286Spermatid developmentIEAbiological_process
GO:0007292Female gamete generationTASbiological_process
GO:0016787Hydrolase activityIEAmolecular_function
GO:0034502Protein localization to chromosomeIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83878938490.64990890160.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0374674803
GSE13712_SHEARDown-0.0854419579
GSE13712_STATICDown-0.1883061524
GSE19018Up0.1661860113
GSE19899_A1Down-0.0395009865
GSE19899_A2Down-0.0377088295
PubMed_21979375_A1Up0.1829239267
PubMed_21979375_A2Up0.0653328115
GSE35957Up0.0799225615
GSE36640Up0.0098956673
GSE54402Up0.0276095479
GSE9593Up0.0258806527
GSE43922Up0.0194052339
GSE24585Down-0.1434091513
GSE37065Down-0.0278279239
GSE28863_A1Down-0.0124881364
GSE28863_A2Down-0.0285390774
GSE28863_A3Up0.0595372690
GSE28863_A4Up0.0296801778
GSE48662Down-0.0256116577

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018949MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.