HCSGD entry for FRK
1. General information
| Official gene symbol | FRK |
|---|---|
| Entrez ID | 2444 |
| Gene full name | fyn-related kinase |
| Other gene symbols | GTK PTK5 RAK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | TAS | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | TAS | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2736406026 | 0.6223611223 | 0.9702713190 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2736727117 |
| GSE13712_SHEAR | Up | 0.0256649348 |
| GSE13712_STATIC | Up | 0.0336304295 |
| GSE19018 | Down | -0.4014999599 |
| GSE19899_A1 | Up | 0.0178423014 |
| GSE19899_A2 | Down | -0.1067590422 |
| PubMed_21979375_A1 | Down | -0.2156805965 |
| PubMed_21979375_A2 | Up | 0.1677592694 |
| GSE35957 | Up | 0.1084758246 |
| GSE36640 | Up | 1.1723749388 |
| GSE54402 | Down | -0.2374498343 |
| GSE9593 | Down | -0.1436203935 |
| GSE43922 | Down | -0.1187186468 |
| GSE24585 | Up | 0.3745455409 |
| GSE37065 | Up | 0.4547385956 |
| GSE28863_A1 | Up | 0.0008920605 |
| GSE28863_A2 | Up | 0.1767728363 |
| GSE28863_A3 | Up | 0.1192497448 |
| GSE28863_A4 | Down | -0.0584832056 |
| GSE48662 | Down | -0.1954530816 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Regorafenib | DB08896 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018568 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
