HCSGD entry for ALOX15B

1. General information

Official gene symbolALOX15B
Entrez ID247
Gene full namearachidonate 15-lipoxygenase, type B
Other gene symbols15-LOX-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005506Iron ion bindingIEAmolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005634NucleusIDA IEAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005856CytoskeletonIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006629Lipid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0008285Negative regulation of cell proliferationIDA IMPbiological_process
GO:0010744Positive regulation of macrophage derived foam cell differentiationIMPbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016165Linoleate 13S-lipoxygenase activityIDAmolecular_function
GO:0016702Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenIEAmolecular_function
GO:0019369Arachidonic acid metabolic processIDA TASbiological_process
GO:0019372Lipoxygenase pathwayTASbiological_process
GO:0030336Negative regulation of cell migrationTASbiological_process
GO:0030850Prostate gland developmentNASbiological_process
GO:0030856Regulation of epithelial cell differentiationNASbiological_process
GO:0035360Positive regulation of peroxisome proliferator activated receptor signaling pathwayIEAbiological_process
GO:0036403Arachidonate 8(S)-lipoxygenase activityIEAmolecular_function
GO:0043651Linoleic acid metabolic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045618Positive regulation of keratinocyte differentiationIEAbiological_process
GO:0045786Negative regulation of cell cycleIDAbiological_process
GO:0045926Negative regulation of growthIDAbiological_process
GO:0050473Arachidonate 15-lipoxygenase activityIDAmolecular_function
GO:0051122Hepoxilin biosynthetic processISSbiological_process
GO:0090197Positive regulation of chemokine secretionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48565786250.86904508950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0967495625
GSE13712_SHEARDown-0.1288472992
GSE13712_STATICDown-0.0189418840
GSE19018Up0.0149308783
GSE19899_A1Up0.0190135626
GSE19899_A2Up0.3004701252
PubMed_21979375_A1Up0.0437138957
PubMed_21979375_A2Up0.0208345244
GSE35957Down-0.0035263380
GSE36640Down-0.0548555326
GSE54402Up0.0376320693
GSE9593Up0.1420502383
GSE43922Up0.0106522344
GSE24585Up0.1306253068
GSE37065Up0.0020759603
GSE28863_A1Down-0.0958977433
GSE28863_A2Down-0.1768133953
GSE28863_A3Up0.3226574931
GSE28863_A4Up0.0782118642
GSE48662Up0.7245443703

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.