HCSGD entry for FSHR

1. General information

Official gene symbol	FSHR
Entrez ID	2492
Gene full name	follicle stimulating hormone receptor
Other gene symbols	FSHRO LGR1 ODG1
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001545	Primary ovarian follicle growth	IEA	biological_process
GO:0001932	Regulation of protein phosphorylation	IEA	biological_process
GO:0003073	Regulation of systemic arterial blood pressure	IEA	biological_process
GO:0004963	Follicle-stimulating hormone receptor activity	IEA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005768	Endosome	IEA	cellular_component
GO:0005886	Plasma membrane	TAS	cellular_component
GO:0007186	G-protein coupled receptor signaling pathway	TAS	biological_process
GO:0007189	Adenylate cyclase-activating G-protein coupled receptor signaling pathway	IEA	biological_process
GO:0007193	Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IEA	biological_process
GO:0007200	Phospholipase C-activating G-protein coupled receptor signaling pathway	IEA	biological_process
GO:0007283	Spermatogenesis	TAS	biological_process
GO:0007292	Female gamete generation	TAS	biological_process
GO:0007626	Locomotory behavior	IEA	biological_process
GO:0008406	Gonad development	TAS	biological_process
GO:0008584	Male gonad development	IEP	biological_process
GO:0008585	Female gonad development	TAS	biological_process
GO:0009986	Cell surface	IEA	cellular_component
GO:0009992	Cellular water homeostasis	IEA	biological_process
GO:0010640	Regulation of platelet-derived growth factor receptor signaling pathway	IEA	biological_process
GO:0016021	Integral component of membrane	IEA	cellular_component
GO:0017046	Peptide hormone binding	IEA	molecular_function
GO:0031175	Neuron projection development	IEA	biological_process
GO:0032350	Regulation of hormone metabolic process	IEA	biological_process
GO:0033044	Regulation of chromosome organization	IEA	biological_process
GO:0033148	Positive regulation of intracellular estrogen receptor signaling pathway	IEA	biological_process
GO:0035093	Spermatogenesis, exchange of chromosomal proteins	IEA	biological_process
GO:0042699	Follicle-stimulating hormone signaling pathway	TAS	biological_process
GO:0043408	Regulation of MAPK cascade	IEA	biological_process
GO:0045056	Transcytosis	IEA	biological_process
GO:0045670	Regulation of osteoclast differentiation	IEA	biological_process
GO:0045779	Negative regulation of bone resorption	IEA	biological_process
GO:0060009	Sertoli cell development	IEA	biological_process
GO:0060011	Sertoli cell proliferation	IEA	biological_process
GO:0060065	Uterus development	IEA	biological_process
GO:0060408	Regulation of acetylcholine metabolic process	IEA	biological_process
GO:0071711	Basement membrane organization	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.7140456214	0.7744938072	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0974763575
GSE13712_SHEAR	Up	0.0336777071
GSE13712_STATIC	Up	0.1085817087
GSE19018	Up	0.1361485182
GSE19899_A1	Up	0.1632632502
GSE19899_A2	Down	-0.1317700238
PubMed_21979375_A1	Down	-0.0153550875
PubMed_21979375_A2	Down	-0.1883494209
GSE35957	Up	0.1633941205
GSE36640	Up	0.0961904842
GSE54402	Up	0.0204510247
GSE9593	Up	0.1112182866
GSE43922	Up	0.0117213437
GSE24585	Down	-0.1405502760
GSE37065	Up	0.0800463592
GSE28863_A1	Down	-0.0149108837
GSE28863_A2	Down	-0.0573286903
GSE28863_A3	Up	0.1282960411
GSE28863_A4	Up	0.0060427761
GSE48662	Up	0.0855375069

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Menotropins	DB00032	BTD00018 \| BIOD00018
Follitropin beta	DB00066	BTD00099 \| BTD00064 \| BIOD00099 \| BIOD00064
Urofollitropin	DB00094	BTD00104 \| BIOD00104
Chorionic Gonadotropin (Recombinant)	DB00097	BTD00034 \| BIOD00034
Suramin	DB04786	-

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for FSHR

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )