HCSGD entry for KDSR
1. General information
| Official gene symbol | KDSR |
|---|---|
| Entrez ID | 2531 |
| Gene full name | 3-ketodihydrosphingosine reductase |
| Other gene symbols | DHSR FVT1 SDR35C1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006666 | 3-keto-sphinganine metabolic process | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047560 | 3-dehydrosphinganine reductase activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0071804833 | 0.9720868128 | 0.2210497076 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4457981390 |
| GSE13712_SHEAR | Down | -0.2018461389 |
| GSE13712_STATIC | Down | -0.2102684068 |
| GSE19018 | Up | 0.1316866743 |
| GSE19899_A1 | Up | 0.6043556304 |
| GSE19899_A2 | Up | 0.8470959171 |
| PubMed_21979375_A1 | Down | -0.1428221851 |
| PubMed_21979375_A2 | Up | 0.7421354796 |
| GSE35957 | Up | 0.2290300672 |
| GSE36640 | Up | 0.9903631784 |
| GSE54402 | Up | 0.3301614491 |
| GSE9593 | Up | 0.8713181895 |
| GSE43922 | Up | 0.5644327983 |
| GSE24585 | Down | -0.3671564048 |
| GSE37065 | Up | 0.3826721271 |
| GSE28863_A1 | Up | 0.0647223427 |
| GSE28863_A2 | Up | 0.9212531399 |
| GSE28863_A3 | Down | -0.2870252613 |
| GSE28863_A4 | Up | 0.1013868800 |
| GSE48662 | Up | 0.1339936662 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019765 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022479 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031566 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042461 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049650 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
