HCSGD entry for DARC
1. General information
| Official gene symbol | DARC |
|---|---|
| Entrez ID | 2532 |
| Gene full name | Duffy blood group, chemokine receptor |
| Other gene symbols | CCBP1 CD234 Dfy FY GPD GpFy WBCQ1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005769 | Early endosome | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006952 | Defense response | NAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019956 | Chemokine binding | IEA | molecular_function |
| GO:0019957 | C-C chemokine binding | IPI | molecular_function |
| GO:0032642 | Regulation of chemokine production | IEA | biological_process |
| GO:0055037 | Recycling endosome | IEA | cellular_component |
| GO:0070098 | Chemokine-mediated signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3417125337 | 0.2777903119 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1815925962 |
| GSE13712_SHEAR | Down | -2.6986447261 |
| GSE13712_STATIC | Down | -0.3571446561 |
| GSE19018 | Up | 0.0202652833 |
| GSE19899_A1 | Up | 0.1229363931 |
| GSE19899_A2 | Down | -0.1576728732 |
| PubMed_21979375_A1 | Up | 0.1437091007 |
| PubMed_21979375_A2 | Down | -0.3116588358 |
| GSE35957 | Up | 0.1086313413 |
| GSE36640 | Down | -0.0253639465 |
| GSE54402 | Up | 0.1414728541 |
| GSE9593 | Up | 0.1892299318 |
| GSE43922 | Up | 0.1512146527 |
| GSE24585 | Down | -0.0697591999 |
| GSE37065 | Up | 0.0051934319 |
| GSE28863_A1 | Up | 0.2694660529 |
| GSE28863_A2 | Up | 0.8516190613 |
| GSE28863_A3 | Up | 0.1348597568 |
| GSE28863_A4 | Up | 0.2447712772 |
| GSE48662 | Up | 0.0380973341 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23873025 | Mechanistic studies showed that inducible expression of CD82 in highly metastatic melanoma cells significantly increased p21 expression upon binding of Duffy antigen receptor group (DARC), inducing tumor cell senescence and interrupting IL-8-mediated vascular endothelial (VE)-cadherin disassembly |
| 17955335 | Duffy antigen/receptor for chemokines (DARC) attenuates angiogenesis by causing senescence in endothelial cells |
| 17955335 | Duffy antigen/receptor for chemokines (DARC), expressed on erythrocytes and post-capillary venular endothelial cells, selectively binds both CXC and CC chemokines |
| 17955335 | DARC binds ELR + angiogenic chemokines such as IL-8 (CXCL8) |
| 17955335 | We show that the DARC on endothelial cells plays a direct role in regulating angiogenesis |
| 17955335 | Matrigel(TM) in vivo plug assay showed that there was more capillary formation in DARC knockout mice compared to wild type mice indicating that DARC attenuated angiogenic activity |
| 17955335 | In vitro angiogenic assay on Matrigel coated plates using DARC expressing stable human cerebro-microvascular endothelial cells (HCEC) showed that, although capillary formation in transfected cells started early within 4-8 h; capillary formation was attenuated within 12-24 h |
| 17955335 | Preincubation of DARC-expressing HCEC with monoclonal antibody (mAb-Fy6) against the N-terminal chemokine-binding domain of DARC increased capillary formation in vitro |
| 17955335 | Interestingly, after several days in the conditioned medium, DARC expressing senescent cells started to initiate capillary formation; whereas capillary formed with DARC non-expressing cells remained the same |
| 17955335 | Our data evidently demonstrated that DARC on endothelial cells attenuated the angiogenic activity by causing senescence |
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