HCSGD entry for GABBR1

1. General information

Official gene symbolGABBR1
Entrez ID2550
Gene full namegamma-aminobutyric acid (GABA) B receptor, 1
Other gene symbolsGABABR1 GABBR1-3 GB1 GPRC3A dJ271M21.1.1 dJ271M21.1.2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004965G-protein coupled GABA receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007194Negative regulation of adenylate cyclase activityTASbiological_process
GO:0007214Gamma-aminobutyric acid signaling pathwayIDA IEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0038037G-protein coupled receptor dimeric complexIEAcellular_component
GO:0038039G-protein coupled receptor heterodimeric complexIPIcellular_component
GO:0042734Presynaptic membraneIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59764388510.31608059720.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3890486119
GSE13712_SHEARDown-0.1051155813
GSE13712_STATICDown-0.0523869980
GSE19018Up0.0356346567
GSE19899_A1Down-0.0085125273
GSE19899_A2Up0.1725424877
PubMed_21979375_A1Down-0.2149230203
PubMed_21979375_A2Up0.3280863926
GSE35957Down-0.4430808542
GSE36640Up0.5477241807
GSE54402Up0.2944620353
GSE9593Up0.1293541687
GSE43922Up0.0288541196
GSE24585Down-0.0903121809
GSE37065Down-0.0081028620
GSE28863_A1Down-0.0480058798
GSE28863_A2Down-0.0188611134
GSE28863_A3Up0.0633080477
GSE28863_A4Down-0.1707132210
GSE48662Down-0.1087545847

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ProgabideDB00837 APRD00072
VigabatrinDB01080 APRD00282
SGS742DB05010 -
ArbaclofenDB08891 -
Arbaclofen PlacarbilDB08892 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017808MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT029420MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.