HCSGD entry for PCSK9

1. General information

Official gene symbolPCSK9
Entrez ID255738
Gene full nameproprotein convertase subtilisin/kexin type 9
Other gene symbolsFH3 HCHOLA3 LDLCQ1 NARC-1 NARC1 PC9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentISSbiological_process
GO:0001889Liver developmentISSbiological_process
GO:0001920Negative regulation of receptor recyclingIDAbiological_process
GO:0002092Positive regulation of receptor internalizationIDAbiological_process
GO:0004252Serine-type endopeptidase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeIDAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005770Late endosomeIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005791Rough endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0006508ProteolysisIBA IEAbiological_process
GO:0006641Triglyceride metabolic processIEAbiological_process
GO:0006644Phospholipid metabolic processIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007041Lysosomal transportIDAbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0009267Cellular response to starvationISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010469Regulation of receptor activityIDAbiological_process
GO:0010989Negative regulation of low-density lipoprotein particle clearanceIDAbiological_process
GO:0016540Protein autoprocessingIDAbiological_process
GO:0019871Sodium channel inhibitor activityIDAmolecular_function
GO:0022008NeurogenesisISSbiological_process
GO:0030169Low-density lipoprotein particle bindingISSmolecular_function
GO:0030182Neuron differentiationISSbiological_process
GO:0031232Extrinsic component of external side of plasma membraneICcellular_component
GO:0032802Low-density lipoprotein particle receptor catabolic processIDAbiological_process
GO:0032803Regulation of low-density lipoprotein particle receptor catabolic processIEAbiological_process
GO:0032869Cellular response to insulin stimulusISSbiological_process
GO:0034185Apolipoprotein bindingISSmolecular_function
GO:0034189Very-low-density lipoprotein particle bindingISSmolecular_function
GO:0034190Apolipoprotein receptor bindingIDAmolecular_function
GO:0042157Lipoprotein metabolic processIEAbiological_process
GO:0042632Cholesterol homeostasisIMPbiological_process
GO:0042802Identical protein bindingIEAmolecular_function
GO:0043086Negative regulation of catalytic activityIEAbiological_process
GO:0043523Regulation of neuron apoptotic processISSbiological_process
GO:0043525Positive regulation of neuron apoptotic processIMPbiological_process
GO:0043621Protein self-associationIDAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050750Low-density lipoprotein particle receptor bindingIDA IPImolecular_function
GO:0070326Very-low-density lipoprotein particle receptor bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39002711900.89134897990.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1365526810
GSE13712_SHEARDown-0.0075484644
GSE13712_STATICDown-0.0561576333
GSE19018Up0.2253141867
GSE19899_A1Up0.1559221531
GSE19899_A2Up0.0853285720
PubMed_21979375_A1Down-0.0147535041
PubMed_21979375_A2Down-0.2323237691
GSE35957Up0.0406755132
GSE36640Up0.0167482526
GSE54402Down-0.0885826491
GSE9593Up0.1911233624
GSE43922Up0.0608642225
GSE24585Up0.1337462032
GSE37065Up0.1020891074
GSE28863_A1Down-0.1007564052
GSE28863_A2Up0.0371849485
GSE28863_A3Up0.3299188380
GSE28863_A4Up0.1011989562
GSE48662Down-0.1343702355

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AlirocumabDB09302 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018980MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT023073MicroarrayFunctional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024487MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026924MicroarrayFunctional MTI (Weak)19074876
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26112889Most of these data were derived from experimental findings in genetically modified mice, where NFkappaB, Pcsk9, low-density lipoprotein-receptor, PPARgamma, superoxide dismutase 2, poly[adenosine diphosphate-ribose] polymerase 1, and endothelial nitric oxide synthase were identified among others as crucial molecular targets and/or partners of sirtuins
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