HCSGD entry for SUN2
1. General information
| Official gene symbol | SUN2 |
|---|---|
| Entrez ID | 25777 |
| Gene full name | Sad1 and UNC84 domain containing 2 |
| Other gene symbols | UNC84B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000784 | Nuclear chromosome, telomeric region | IEA | cellular_component |
| GO:0000794 | Condensed nuclear chromosome | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005521 | Lamin binding | IDA | molecular_function |
| GO:0005635 | Nuclear envelope | IDA TAS | cellular_component |
| GO:0005637 | Nuclear inner membrane | IEA | cellular_component |
| GO:0006998 | Nuclear envelope organization | IGI | biological_process |
| GO:0007052 | Mitotic spindle organization | TAS | biological_process |
| GO:0007097 | Nuclear migration | TAS | biological_process |
| GO:0008017 | Microtubule binding | TAS | molecular_function |
| GO:0010008 | Endosome membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030335 | Positive regulation of cell migration | IEA ISS | biological_process |
| GO:0031022 | Nuclear migration along microfilament | IEA ISS | biological_process |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0034993 | SUN-KASH complex | IDA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0051642 | Centrosome localization | IEA ISS | biological_process |
| GO:0090286 | Cytoskeletal anchoring at nuclear membrane | IDA | biological_process |
| GO:0090292 | Nuclear matrix anchoring at nuclear membrane | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9039010486 | 0.0152176855 | 0.9999902473 | 0.2424604722 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6682690245 |
| GSE13712_SHEAR | Down | -0.5142269128 |
| GSE13712_STATIC | Down | -0.3916747942 |
| GSE19018 | Up | 0.2985453249 |
| GSE19899_A1 | Down | -0.3737309377 |
| GSE19899_A2 | Down | -0.1825679382 |
| PubMed_21979375_A1 | Down | -1.1413374521 |
| PubMed_21979375_A2 | Down | -0.5042019953 |
| GSE35957 | Down | -0.6843045850 |
| GSE36640 | Down | -0.6425740856 |
| GSE54402 | Down | -0.7715578649 |
| GSE9593 | Down | -0.3022095128 |
| GSE43922 | Up | 0.0480701280 |
| GSE24585 | Down | -0.1919124528 |
| GSE37065 | Down | -0.1739111940 |
| GSE28863_A1 | Up | 0.4593821456 |
| GSE28863_A2 | Up | 0.3175222890 |
| GSE28863_A3 | Down | -0.3948728170 |
| GSE28863_A4 | Up | 0.0055606910 |
| GSE48662 | Up | 0.7654012703 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020123 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027033 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036434 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046749 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047952 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT050037 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26029982 | Surprisingly, p53 disabled tumor cells could be forced into senescence by expression of a mutant allele of the nuclear envelope protein lamin A |
| 22541428 | Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies |
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