HCSGD entry for DSTYK
1. General information
| Official gene symbol | DSTYK |
|---|---|
| Entrez ID | 25778 |
| Gene full name | dual serine/threonine and tyrosine protein kinase |
| Other gene symbols | DustyPK RIP5 RIPK5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004712 | Protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8008438889 | 0.0555820296 | 0.9999902473 | 0.4437290264 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0070155464 |
| GSE13712_SHEAR | Down | -0.1141993087 |
| GSE13712_STATIC | Up | 0.0753021521 |
| GSE19018 | Down | -0.0622679536 |
| GSE19899_A1 | Down | -0.2514493159 |
| GSE19899_A2 | Down | -0.3648402615 |
| PubMed_21979375_A1 | Down | -1.0602869110 |
| PubMed_21979375_A2 | Down | -0.4400911268 |
| GSE35957 | Up | 0.1500831792 |
| GSE36640 | Up | 0.1646942951 |
| GSE54402 | Down | -0.2324115687 |
| GSE9593 | Up | 0.2811568519 |
| GSE43922 | Down | -0.1533090439 |
| GSE24585 | Down | -0.0097283316 |
| GSE37065 | Up | 0.0184910743 |
| GSE28863_A1 | Up | 0.5682128031 |
| GSE28863_A2 | Up | 0.4126887201 |
| GSE28863_A3 | Down | -1.0347126540 |
| GSE28863_A4 | Down | -0.4099915913 |
| GSE48662 | Up | 0.1229435911 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003727 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020282 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT026003 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026422 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028170 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT051344 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
