HCSGD entry for POLR1A

1. General information

Official gene symbolPOLR1A
Entrez ID25885
Gene full namepolymerase (RNA) I polypeptide A, 194kDa
Other gene symbolsA190 RPA1 RPA194 RPO1-4 RPO14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001054RNA polymerase I activityIBAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003899DNA-directed RNA polymerase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005736DNA-directed RNA polymerase I complexIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterTASbiological_process
GO:0006362Transcription elongation from RNA polymerase I promoterTASbiological_process
GO:0006363Termination of RNA polymerase I transcriptionTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05225439000.79807144110.50021057801.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0434195652
GSE13712_SHEARUp0.2752555847
GSE13712_STATICUp0.1939671971
GSE19018Up0.0062461541
GSE19899_A1Down-0.0920685370
GSE19899_A2Up0.2088467565
PubMed_21979375_A1Up0.1902126909
PubMed_21979375_A2Up0.2253334868
GSE35957Down-0.0860044620
GSE36640Down-0.0245058098
GSE54402Up0.2399111903
GSE9593Down-0.2878365210
GSE43922Up0.4775896310
GSE24585Down-0.3010954528
GSE37065Down-0.2097226004
GSE28863_A1Up0.9768205143
GSE28863_A2Up1.2898777636
GSE28863_A3Up0.1643342470
GSE28863_A4Down-0.1439715084
GSE48662Up0.2807274329

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT032207ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT040172CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.