HCSGD entry for POT1
1. General information
| Official gene symbol | POT1 |
|---|---|
| Entrez ID | 25913 |
| Gene full name | protection of telomeres 1 |
| Other gene symbols | HPOT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000723 | Telomere maintenance | IEA TAS | biological_process |
| GO:0000781 | Chromosome, telomeric region | IDA | cellular_component |
| GO:0000783 | Nuclear telomere cap complex | IDA | cellular_component |
| GO:0000784 | Nuclear chromosome, telomeric region | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0007004 | Telomere maintenance via telomerase | IDA | biological_process |
| GO:0010521 | Telomerase inhibitor activity | IDA | molecular_function |
| GO:0016233 | Telomere capping | IGI IMP | biological_process |
| GO:0017151 | DEAD/H-box RNA helicase binding | IPI | molecular_function |
| GO:0032203 | Telomere formation via telomerase | IDA | biological_process |
| GO:0032211 | Negative regulation of telomere maintenance via telomerase | IMP | biological_process |
| GO:0032212 | Positive regulation of telomere maintenance via telomerase | IMP | biological_process |
| GO:0032508 | DNA duplex unwinding | IDA | biological_process |
| GO:0043047 | Single-stranded telomeric DNA binding | IDA IEA IMP | molecular_function |
| GO:0051096 | Positive regulation of helicase activity | IDA | biological_process |
| GO:0051973 | Positive regulation of telomerase activity | IDA | biological_process |
| GO:0051974 | Negative regulation of telomerase activity | IDA | biological_process |
| GO:0060383 | Positive regulation of DNA strand elongation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7717943467 | 0.0058920064 | 0.9999902473 | 0.1551324351 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0458165260 |
| GSE13712_SHEAR | Down | -0.2941117915 |
| GSE13712_STATIC | Down | -0.3050969347 |
| GSE19018 | Up | 0.1275300619 |
| GSE19899_A1 | Down | -0.6983512524 |
| GSE19899_A2 | Down | -1.9493347295 |
| PubMed_21979375_A1 | Up | 0.0253355508 |
| PubMed_21979375_A2 | Down | -1.5997370631 |
| GSE35957 | Down | -0.7098517676 |
| GSE36640 | Down | -1.2138639517 |
| GSE54402 | Down | -0.2473408502 |
| GSE9593 | Down | -0.4532745259 |
| GSE43922 | Down | -0.5780029553 |
| GSE24585 | Up | 0.0938670538 |
| GSE37065 | Up | 0.1077627954 |
| GSE28863_A1 | Up | 0.1082274146 |
| GSE28863_A2 | Up | 0.5871549339 |
| GSE28863_A3 | Down | -0.9687554064 |
| GSE28863_A4 | Down | -0.2771358643 |
| GSE48662 | Up | 1.7669054160 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26462146 | Ber8 could then induce the delocalization of TRF1 and POT1 from the telomere accompanied by a rapid telomere uncapping |
| 26345860 | Based on the established cell replicative senescence model, reverse transcription-polymerase chain reaction and western blot analyses were used to detect telomere-associated factor expression at the mRNA and protein levels, including that of human telomere binding protein 1, tankyrase 1, telomerase RNA, telomere protection protein 1 (POT1), and p53 during the process of human embryonic lung fibroblast replicative senescence |
| 26345860 | The results showed that transcription of human telomere binding protein 1 did not change with cell senescence, whereas the protein expression of human telomere binding protein 1 increased gradually and then decreased rapidly; there was no change in the mRNA and protein expression of POT1; with the replicative senescence of human embryonic lung fibroblasts, expression of POT1 decreased gradually; TRF1 showed an increasing trend with cell senescence; and p53 protein expression did not change |
| 26345860 | Together, the results from this study suggest that human telomere binding protein 1, POT1, and TRF1 played important roles in cell senescence |
| 23514618 | Gene array qPCR analysis of MIA PaCa-2 cells treated with the lead compound revealed significant dose-dependent modulation of a distinct subset of genes, including strong induction of DNA damage responsive genes CDKN1A, DDIT3, GADD45A/G, and PPM1D, and repression of genes involved in telomere maintenance, including hPOT1 and PARP1 |
| 19067655 | We have tested this hypothesis in a cohort of preimplantation human renal allograft biopsies ( n = 75) that have been assayed by real-time polymerase chain reaction for the expression of known markers of cellular damage and biological aging, including CDKN2A, CDKN1A, SIRT2 and POT1 |
| 19067655 | POT1 expression also showed a significant association with this parameter ( p = 0 |
| 18778766 | Together, our results show that short G-rich single-stranded oligonucleotides induce telomere uncapping in a cell cycle-dependent manner, probably by titrating essential factors like Pot1 away from telomeres |
| 18089797 | Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence |
| 18089797 | Protection of telomeres 1 (POT1) proteins in various organisms bind telomeres and regulate their structure and function |
| 18089797 | In contrast to mice carrying two distinct POT1 genes encoding two POT1 proteins (POT1a and POT1b), humans have the single POT1 gene |
| 18089797 | In addition to full-length POT1 protein (variant v1), the human POT1 gene encodes four other variants due to alternative RNA splicing (variants v2, v3, v4, and v5), whose functions are poorly understood |
| 18089797 | The functional analyses of the NH(2)-terminally and COOH-terminally truncated POT1 variants in this study showed that neither the single-stranded telomere-binding ability of the NH(2)-terminal oligonucleotide-binding (OB) folds nor the telomerase-dependent telomere elongation activity mediated by the COOH-terminal TPP1-interacting domain was telomere protective by itself |
| 18089797 | This study highlights a human-specific complexity in telomere protection and damage signaling conferred by functionally distinct isoforms from the single POT1 gene |
| 17284852 | To understand the telomere regulation mechanism in relation to cell aging and cancer, we examined the single-stranded telomeric DNA binding domain (ssDBD) of fission yeast telomere-binding protein Pot1 by constructing a series of deletion mutants |
| 15000677 | Chromosome telomeres of humans and many model organisms contain a structure called a t-loop, which is maintained by TERF, TINF2, Pot1, and other proteins |
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