HCSGD entry for CLIC4
1. General information
| Official gene symbol | CLIC4 |
|---|---|
| Entrez ID | 25932 |
| Gene full name | chloride intracellular channel 4 |
| Other gene symbols | CLIC4L H1 MTCLIC huH1 p64H1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001886 | Endothelial cell morphogenesis | IEA | biological_process |
| GO:0005247 | Voltage-gated chloride channel activity | IEA | molecular_function |
| GO:0005254 | Chloride channel activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005902 | Microvillus | IDA | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0006821 | Chloride transport | NAS | biological_process |
| GO:0007035 | Vacuolar acidification | IEA | biological_process |
| GO:0009566 | Fertilization | IEA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0015629 | Actin cytoskeleton | TAS | cellular_component |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0016363 | Nuclear matrix | IDA | cellular_component |
| GO:0030154 | Cell differentiation | TAS | biological_process |
| GO:0030216 | Keratinocyte differentiation | IMP | biological_process |
| GO:0030336 | Negative regulation of cell migration | IDA | biological_process |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0030659 | Cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0034707 | Chloride channel complex | IEA | cellular_component |
| GO:0035088 | Establishment or maintenance of apical/basal cell polarity | NAS | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0045177 | Apical part of cell | IDA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0048754 | Branching morphogenesis of an epithelial tube | IEA | biological_process |
| GO:0051493 | Regulation of cytoskeleton organization | NAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0061299 | Retina vasculature morphogenesis in camera-type eye | IEA | biological_process |
| GO:0071277 | Cellular response to calcium ion | IMP | biological_process |
| GO:1902476 | Chloride transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4298149842 | 0.0439823449 | 0.9999902473 | 0.3944324702 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6029876603 |
| GSE13712_SHEAR | Up | 0.4338725453 |
| GSE13712_STATIC | Down | -0.0278194422 |
| GSE19018 | Up | 0.3183557255 |
| GSE19899_A1 | Down | -0.7216212519 |
| GSE19899_A2 | Down | -0.5429967911 |
| PubMed_21979375_A1 | Down | -0.8415974322 |
| PubMed_21979375_A2 | Down | -1.0923523574 |
| GSE35957 | Up | 0.9472593777 |
| GSE36640 | Up | 0.0689394069 |
| GSE54402 | Down | -0.4178808354 |
| GSE9593 | Up | 0.6224085588 |
| GSE43922 | Down | -0.2740476592 |
| GSE24585 | Up | 0.4932292048 |
| GSE37065 | Down | -0.0480529253 |
| GSE28863_A1 | Down | -0.0219098810 |
| GSE28863_A2 | Down | -0.1838753990 |
| GSE28863_A3 | Down | -0.0591315185 |
| GSE28863_A4 | Down | -0.0378723552 |
| GSE48662 | Down | -0.2289621770 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016555 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018964 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020967 | Proteomics | Functional MTI (Weak) | 20584899 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021633 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023398 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-10a-3p | MIMAT0004555 | MIRT038674 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT044169 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050194 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
