HCSGD entry for ULK3
1. General information
| Official gene symbol | ULK3 |
|---|---|
| Entrez ID | 25989 |
| Gene full name | unc-51-like kinase 3 (C. elegans) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000407 | Pre-autophagosomal structure | TAS | cellular_component |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006914 | Autophagy | TAS | biological_process |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0045879 | Negative regulation of smoothened signaling pathway | IDA | biological_process |
| GO:0045880 | Positive regulation of smoothened signaling pathway | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0090398 | Cellular senescence | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0243779226 | 0.8689394932 | 0.3696991935 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0568528533 |
| GSE13712_SHEAR | Up | 0.2890941328 |
| GSE13712_STATIC | Up | 0.1704978636 |
| GSE19018 | Down | -0.1529104863 |
| GSE19899_A1 | Up | 0.4168590972 |
| GSE19899_A2 | Up | 1.1893505410 |
| PubMed_21979375_A1 | Up | 2.1326134133 |
| PubMed_21979375_A2 | Up | 1.2294055297 |
| GSE35957 | Down | -0.6068368804 |
| GSE36640 | Up | 0.3598472944 |
| GSE54402 | Up | 0.6149487478 |
| GSE9593 | Down | -0.4370961372 |
| GSE43922 | Up | 0.5861317416 |
| GSE24585 | Down | -0.2414654078 |
| GSE37065 | Down | -0.0168840872 |
| GSE28863_A1 | Down | -0.1357270662 |
| GSE28863_A2 | Up | 0.1604060612 |
| GSE28863_A3 | Up | 0.0467150455 |
| GSE28863_A4 | Up | 0.0623282391 |
| GSE48662 | Down | -0.1865645381 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | MIRT004992 | Microarray | Functional MTI (Weak) | 17891175 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037732 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21858089 | In contrast to the lifespan extension effect in lower organisms, it has been reported that overexpression of unc-51-like kinase 3 (ULK3), the mammalian homolog of autophagy-specific gene 1 (ATG1), induces premature senescence in human fibroblasts |
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