HCSGD entry for IBTK
1. General information
| Official gene symbol | IBTK |
|---|---|
| Entrez ID | 25998 |
| Gene full name | inhibitor of Bruton agammaglobulinemia tyrosine kinase |
| Other gene symbols | BTBD26 BTKI RP1-93K22.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001933 | Negative regulation of protein phosphorylation | IDA | biological_process |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IDA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0019901 | Protein kinase binding | IDA | molecular_function |
| GO:0030292 | Protein tyrosine kinase inhibitor activity | IDA | molecular_function |
| GO:0043086 | Negative regulation of catalytic activity | IDA | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IDA | biological_process |
| GO:0050790 | Regulation of catalytic activity | IDA | biological_process |
| GO:0051209 | Release of sequestered calcium ion into cytosol | IDA | biological_process |
| GO:0061099 | Negative regulation of protein tyrosine kinase activity | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8729666350 | 0.1978658258 | 0.9999902473 | 0.8601435178 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1167871965 |
| GSE13712_SHEAR | Up | 0.1652019509 |
| GSE13712_STATIC | Up | 0.1008941765 |
| GSE19018 | Down | -0.0482338840 |
| GSE19899_A1 | Down | -0.0005860444 |
| GSE19899_A2 | Down | -0.1292504875 |
| PubMed_21979375_A1 | Up | 0.0215477477 |
| PubMed_21979375_A2 | Up | 0.0109320879 |
| GSE35957 | Down | -0.0441365300 |
| GSE36640 | Up | 0.0016317500 |
| GSE54402 | Up | 0.0258224350 |
| GSE9593 | Down | -0.2024168218 |
| GSE43922 | Down | -0.0847162867 |
| GSE24585 | Up | 0.1131860627 |
| GSE37065 | Down | -0.0720856865 |
| GSE28863_A1 | Up | 0.2255545201 |
| GSE28863_A2 | Up | 0.3479034423 |
| GSE28863_A3 | Down | -0.6828350436 |
| GSE28863_A4 | Down | -0.3390301127 |
| GSE48662 | Down | -0.3566147788 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018477 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045378 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051292 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
