HCSGD entry for GARS
1. General information
| Official gene symbol | GARS |
|---|---|
| Entrez ID | 2617 |
| Gene full name | glycyl-tRNA synthetase |
| Other gene symbols | CMT2D DSMAV GlyRS HMN5 SMAD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004820 | Glycine-tRNA ligase activity | IDA TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006426 | Glycyl-tRNA aminoacylation | IEA | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0015966 | Diadenosine tetraphosphate biosynthetic process | IDA | biological_process |
| GO:0030141 | Secretory granule | IEA | cellular_component |
| GO:0046983 | Protein dimerization activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2285055355 | 0.3500233540 | 0.9104862570 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1162416345 |
| GSE13712_SHEAR | Up | 0.1597793406 |
| GSE13712_STATIC | Up | 0.3788618001 |
| GSE19018 | Up | 1.0578016660 |
| GSE19899_A1 | Up | 0.5167144336 |
| GSE19899_A2 | Down | -0.0862476025 |
| PubMed_21979375_A1 | Up | 0.1874088949 |
| PubMed_21979375_A2 | Down | -0.0047936013 |
| GSE35957 | Down | -0.3165363810 |
| GSE36640 | Down | -0.0317823317 |
| GSE54402 | Down | -0.0650576798 |
| GSE9593 | Up | 0.4849553983 |
| GSE43922 | Up | 0.0522349789 |
| GSE24585 | Down | -0.1674534412 |
| GSE37065 | Down | -0.3746953508 |
| GSE28863_A1 | Down | -0.1083826189 |
| GSE28863_A2 | Down | -0.1851036666 |
| GSE28863_A3 | Down | -0.1977070705 |
| GSE28863_A4 | Down | -0.2951102135 |
| GSE48662 | Up | 0.0406054155 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glycine | DB00145 | NUTR00028 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT032031 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048848 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051856 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22370639 | The tumor-suppressive effect of ZNF331 is mediated at least by downregulation of genes involved in cell growth promotion (DSTN, EIF5A, GARS, DDX5, STAM, UQCRFS1 and SET) and migration/invasion (DSTN and ACTR3), and upregulation of genome-stability gene (SSBP1) and cellular senescence gene (PNPT1) |
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