HCSGD entry for SERGEF

1. General information

Official gene symbolSERGEF
Entrez ID26297
Gene full namesecretion regulating guanine nucleotide exchange factor
Other gene symbolsDELGEF Gnefr
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005087Ran guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0032316Regulation of Ran GTPase activityTASbiological_process
GO:0032318Regulation of Ras GTPase activityTASbiological_process
GO:0043087Regulation of GTPase activityTASbiological_process
GO:0045111Intermediate filament cytoskeletonIDAcellular_component
GO:0050709Negative regulation of protein secretionIDA IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92213685270.27522745720.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0257635796
GSE13712_SHEARDown-0.5337231201
GSE13712_STATICDown-0.0898366287
GSE19018Up0.1452117209
GSE19899_A1Down-0.0201530421
GSE19899_A2Up0.0420321093
PubMed_21979375_A1Down-0.1137053367
PubMed_21979375_A2Down-0.2082297003
GSE35957Down-0.0209186010
GSE36640Up0.1519650601
GSE54402Down-0.2515076047
GSE9593Up0.1861551759
GSE43922Up0.0566658992
GSE24585Down-0.3330398561
GSE37065Up0.0471060010
GSE28863_A1Down-0.1392721659
GSE28863_A2Down-0.0345116800
GSE28863_A3Down-0.0915092371
GSE28863_A4Up0.0601030604
GSE48662Down-0.1433465451

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-24-3pMIMAT0000080MIRT030574MicroarrayFunctional MTI (Weak)19748357
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.