HCSGD entry for GCK

1. General information

Official gene symbolGCK
Entrez ID2645
Gene full nameglucokinase (hexokinase 4)
Other gene symbolsFGQTL3 GK GLK HHF3 HK4 HKIV HXKP LGLK MODY2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001678Cellular glucose homeostasisIBAbiological_process
GO:0004340Glucokinase activityIDAmolecular_function
GO:0004396Hexokinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005536Glucose bindingIDAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0005978Glycogen biosynthetic processIEAbiological_process
GO:0006003Fructose 2,6-bisphosphate metabolic processIEAbiological_process
GO:0006096GlycolysisIEAbiological_process
GO:0006110Regulation of glycolysisNASbiological_process
GO:0006739NADP metabolic processIEAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0008645Hexose transportTASbiological_process
GO:0008865Fructokinase activityIBAmolecular_function
GO:0010827Regulation of glucose transportTASbiological_process
GO:0015758Glucose transportTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0016773Phosphotransferase activity, alcohol group as acceptorIEAmolecular_function
GO:0019158Mannokinase activityIBAmolecular_function
GO:0019903Protein phosphatase bindingIEAmolecular_function
GO:0019932Second-messenger-mediated signalingIEAbiological_process
GO:0030141Secretory granuleIEAcellular_component
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0032024Positive regulation of insulin secretionIMPbiological_process
GO:0032811Negative regulation of epinephrine secretionIEAbiological_process
GO:0032869Cellular response to insulin stimulusISSbiological_process
GO:0042149Cellular response to glucose starvationIEAbiological_process
GO:0042327Positive regulation of phosphorylationIEAbiological_process
GO:0042593Glucose homeostasisIMPbiological_process
GO:0043266Regulation of potassium ion transportIEAbiological_process
GO:0043531ADP bindingIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044320Cellular response to leptin stimulusISSbiological_process
GO:0045721Negative regulation of gluconeogenesisIMPbiological_process
GO:0045725Positive regulation of glycogen biosynthetic processIMPbiological_process
GO:0045821Positive regulation of glycolysisIEAbiological_process
GO:0050796Regulation of insulin secretionIMPbiological_process
GO:0051594Detection of glucoseIMPbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0070509Calcium ion importIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83312817520.66795149120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0907205761
GSE13712_SHEARDown-0.0755830975
GSE13712_STATICDown-0.1566558419
GSE19018Up0.0592856139
GSE19899_A1Down-0.0861036216
GSE19899_A2Down-0.0824561282
PubMed_21979375_A1Up0.0105009416
PubMed_21979375_A2Down-0.0872376307
GSE35957Down-0.0638452238
GSE36640Down-0.0470199855
GSE54402Down-0.0252710202
GSE9593Down-0.0153584407
GSE43922Up0.0679485574
GSE24585Up0.1976358707
GSE37065Down-0.0688826626
GSE28863_A1Down-0.1134368566
GSE28863_A2Up0.0684484558
GSE28863_A3Up0.2414902051
GSE28863_A4Up0.0130544450
GSE48662Up0.2408285562

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Beta-D-GlucoseDB02379 EXPT00685 | EXPT00455 | EXPT01603
2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamideDB07358 -
3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamideDB07359 -
2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamideDB08118 -
2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDEDB08210 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018730MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23583398Real-time PCR followed by screening with focused DNA array analysis revealed up-regulated expression of glucokinase (1
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