HCSGD entry for KAT2A
1. General information
| Official gene symbol | KAT2A |
|---|---|
| Entrez ID | 2648 |
| Gene full name | K(lysine) acetyltransferase 2A |
| Other gene symbols | GCN5 GCN5L2 PCAF-b hGCN5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001756 | Somitogenesis | IEA | biological_process |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0004402 | Histone acetyltransferase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IDA IEA | cellular_component |
| GO:0006338 | Chromatin remodeling | TAS | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0008080 | N-acetyltransferase activity | IEA | molecular_function |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0010484 | H3 histone acetyltransferase activity | IDA IEA | molecular_function |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016578 | Histone deubiquitination | IDA | biological_process |
| GO:0021537 | Telencephalon development | IEA | biological_process |
| GO:0022037 | Metencephalon development | IEA | biological_process |
| GO:0030901 | Midbrain development | IEA | biological_process |
| GO:0030914 | STAGA complex | IDA IEA | cellular_component |
| GO:0031647 | Regulation of protein stability | IMP | biological_process |
| GO:0033276 | Transcription factor TFTC complex | IDA | cellular_component |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0043966 | Histone H3 acetylation | IDA | biological_process |
| GO:0043997 | Histone acetyltransferase activity (H4-K12 specific) | IEA | molecular_function |
| GO:0044154 | Histone H3-K14 acetylation | IEA | biological_process |
| GO:0072686 | Mitotic spindle | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1375570495 | 0.2248988336 | 0.7473283326 | 0.9121051156 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0150267873 |
| GSE13712_SHEAR | Down | -0.2976071635 |
| GSE13712_STATIC | Down | -0.3318379960 |
| GSE19018 | Up | 0.0833607865 |
| GSE19899_A1 | Up | 0.3415855607 |
| GSE19899_A2 | Up | 0.8613309907 |
| PubMed_21979375_A1 | Up | 0.4126933313 |
| PubMed_21979375_A2 | Up | 0.8223448701 |
| GSE35957 | Down | -0.3724034564 |
| GSE36640 | Up | 0.1532041661 |
| GSE54402 | Up | 0.0465156510 |
| GSE9593 | Down | -0.2676254706 |
| GSE43922 | Up | 0.5736237311 |
| GSE24585 | Down | -0.8604290452 |
| GSE37065 | Up | 0.0016134304 |
| GSE28863_A1 | Up | 0.2348061382 |
| GSE28863_A2 | Up | 0.4844819063 |
| GSE28863_A3 | Down | -0.2075438182 |
| GSE28863_A4 | Down | -0.0486416220 |
| GSE48662 | Down | -0.7416938523 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Coenzyme A | DB01992 | EXPT00991 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022532 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023698 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039857 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043446 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047064 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049612 | CLASH//qRT-PCR | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050843 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11707903 | Cross-linking experiments indicated that NF-Y may interact with proteins such as GCN5 and P/CAF |
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