HCSGD entry for GH1

1. General information

Official gene symbolGH1
Entrez ID2688
Gene full namegrowth hormone 1
Other gene symbolsGH GH-N GHN IGHD1B hGH-N
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002092Positive regulation of receptor internalizationIDAbiological_process
GO:0005131Growth hormone receptor bindingIDA IPImolecular_function
GO:0005148Prolactin receptor bindingIPImolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0007259JAK-STAT cascadeIDAbiological_process
GO:0008083Growth factor activityIPImolecular_function
GO:0010535Positive regulation of activation of JAK2 kinase activityIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0015758Glucose transportIDAbiological_process
GO:0032355Response to estradiolIDAbiological_process
GO:0040018Positive regulation of multicellular organism growthIDA IMPbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinIDAbiological_process
GO:0043406Positive regulation of MAP kinase activityTASbiological_process
GO:0043568Positive regulation of insulin-like growth factor receptor signaling pathwayIDAbiological_process
GO:0046427Positive regulation of JAK-STAT cascadeIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0060396Growth hormone receptor signaling pathwayIDAbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0070977Bone maturationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.56649969610.53783269630.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0505026982
GSE13712_SHEARUp0.0836250934
GSE13712_STATICDown-0.0038375036
GSE19018Up0.0953039317
GSE19899_A1Down-0.0170193660
GSE19899_A2Down-0.0510776820
PubMed_21979375_A1Down-0.0194761519
PubMed_21979375_A2Up0.0204535497
GSE35957Up0.0241136006
GSE36640Down-0.0460166144
GSE54402Up0.0761061915
GSE9593Up0.0529509829
GSE43922Down-0.0023883628
GSE24585Down-0.0411611147
GSE37065Down-0.0451341007
GSE28863_A1Up0.1860801414
GSE28863_A2Up0.1225467562
GSE28863_A3Up0.2345236051
GSE28863_A4Down-0.2993009300
GSE48662Up0.0131870371

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.