HCSGD entry for GHRH

1. General information

Official gene symbolGHRH
Entrez ID2691
Gene full namegrowth hormone releasing hormone
Other gene symbolsGHRF GRF INN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceISScellular_component
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIC IDA ISSbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0016608Growth hormone-releasing hormone activityIDAmolecular_function
GO:0019933CAMP-mediated signalingIDAbiological_process
GO:0021984Adenohypophysis developmentISSbiological_process
GO:0030252Growth hormone secretionIDAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0031770Growth hormone-releasing hormone receptor bindingIPImolecular_function
GO:0032094Response to foodISSbiological_process
GO:0040018Positive regulation of multicellular organism growthIMPbiological_process
GO:0043195Terminal boutonISScellular_component
GO:0043568Positive regulation of insulin-like growth factor receptor signaling pathwayNASbiological_process
GO:0046005Positive regulation of circadian sleep/wake cycle, REM sleepIMP NASbiological_process
GO:0060124Positive regulation of growth hormone secretionIDA IMP NASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60848154330.85358964330.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1172315919
GSE13712_SHEARDown-0.1194515265
GSE13712_STATICDown-0.0394752215
GSE19018Down-0.1619786316
GSE19899_A1Up0.1698772723
GSE19899_A2Down-0.0507308600
PubMed_21979375_A1Down-0.1030774819
PubMed_21979375_A2Up0.0555107650
GSE35957Down-0.0823246106
GSE36640Up0.0600556767
GSE54402Up0.0265601183
GSE9593Down-0.0279016816
GSE43922Up0.0364447333
GSE24585Down-0.0035564432
GSE37065Up0.0286840489
GSE28863_A1Up0.0832345316
GSE28863_A2Down-0.0156635709
GSE28863_A3Up0.3005332457
GSE28863_A4Up0.0425396114
GSE48662Up0.1107120460

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19342460Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation
19342460Hyperactivation of the GHRH receptor or downstream signaling components is associated with hyperplasia of the pituitary somatotrope population, in which adenomas form relatively late in life, with less than 100% penetrance
19342460Hyperplastic and adenomatous pituitaries of metallothionein promoter-human GHRH transgenic (Tg) mice (4 and > 10 months, respectively) were used to identify mechanisms that may prevent or delay adenoma formation in the presence of excess GHRH
9892847Coincubation of thymulin with GHRH revealed a semiadditive release of GH in young and middle-aged AP cells and an additive effect in senescent cells
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