HCSGD entry for DISC1

1. General information

Official gene symbolDISC1
Entrez ID27185
Gene full namedisrupted in schizophrenia 1
Other gene symbolsC1orf136 SCZD9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIMPbiological_process
GO:0001764Neuron migrationIMPbiological_process
GO:0002052Positive regulation of neuroblast proliferationIGIbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0008104Protein localizationIEAbiological_process
GO:0010975Regulation of neuron projection developmentIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0021799Cerebral cortex radially oriented cell migrationIEAbiological_process
GO:0021846Cell proliferation in forebrainIEAbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030177Positive regulation of Wnt signaling pathwayIGIbiological_process
GO:0031929TOR signalingIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0051560Mitochondrial calcium ion homeostasisIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0090128Regulation of synapse maturationIEAbiological_process
GO:2000060Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60312511680.90715622890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0066957263
GSE13712_SHEARUp0.1856103074
GSE13712_STATICUp0.1168867817
GSE19018Down-0.0234786439
GSE19899_A1Up0.2830582355
GSE19899_A2Up0.1368983985
PubMed_21979375_A1Down-0.0682869322
PubMed_21979375_A2Down-0.0485586315
GSE35957Up0.0454472563
GSE36640Down-0.0890377426
GSE54402Up0.0646845934
GSE9593Up0.0096925175
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0534677014
GSE28863_A2Up0.3606290705
GSE28863_A3Up0.0263950629
GSE28863_A4Down-0.1334411120
GSE48662Up0.0214086256

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT023117MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.