HCSGD entry for GNMT
1. General information
| Official gene symbol | GNMT |
|---|---|
| Entrez ID | 27232 |
| Gene full name | glycine N-methyltransferase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005542 | Folic acid binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005977 | Glycogen metabolic process | IEA | biological_process |
| GO:0006111 | Regulation of gluconeogenesis | IEA | biological_process |
| GO:0006464 | Cellular protein modification process | NAS | biological_process |
| GO:0006555 | Methionine metabolic process | IEA | biological_process |
| GO:0006730 | One-carbon metabolic process | IEA | biological_process |
| GO:0016594 | Glycine binding | IDA | molecular_function |
| GO:0017174 | Glycine N-methyltransferase activity | IDA | molecular_function |
| GO:0046500 | S-adenosylmethionine metabolic process | IDA | biological_process |
| GO:0051289 | Protein homotetramerization | IPI | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3641784811 | 0.8928855059 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0541176157 |
| GSE13712_SHEAR | Up | 0.0593700981 |
| GSE13712_STATIC | Down | -0.1166061334 |
| GSE19018 | Up | 0.0601258209 |
| GSE19899_A1 | Up | 0.1409620281 |
| GSE19899_A2 | Down | -0.2142082783 |
| PubMed_21979375_A1 | Up | 0.0051874122 |
| PubMed_21979375_A2 | Down | -0.1003801102 |
| GSE35957 | Up | 0.1814153869 |
| GSE36640 | Up | 0.1860495424 |
| GSE54402 | Up | 0.0728552738 |
| GSE9593 | Down | -0.0753209622 |
| GSE43922 | Up | 0.0349556283 |
| GSE24585 | Up | 0.2310255560 |
| GSE37065 | Up | 0.1068170022 |
| GSE28863_A1 | Up | 0.0127179033 |
| GSE28863_A2 | Up | 0.3549104590 |
| GSE28863_A3 | Up | 0.1431446445 |
| GSE28863_A4 | Down | -0.0031369880 |
| GSE48662 | Up | 0.0237504413 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glycine | DB00145 | NUTR00028 |
| S-Adenosyl-L-Homocysteine | DB01752 | EXPT02842 |
| Citric Acid | DB04272 | EXPT00922 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016781 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22160218 | Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma |
| 22160218 | We hypothesized that GNMT may regulate signal transduction through interacting with other proteins directly |
| 22160218 | Fluorescence resonance energy transfer assay demonstrated that the C-terminal half of GNMT interact with the PSD-95/Dlg1/ZO-1 (PDZ) domain of DEPDC6/DEPTOR |
| 22160218 | Overexpression of GNMT caused activation of mTOR/raptor downstream signaling and delayed G2/M cell cycle progression, which altogether resulted in cellular senescence |
| 22160218 | Furthermore, GNMT reduced proliferation of HuH-7 cells and sensitized them to rapamycin treatment both in vitro and in vivo |
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