HCSGD entry for KLHL20
1. General information
| Official gene symbol | KLHL20 |
|---|---|
| Entrez ID | 27252 |
| Gene full name | kelch-like family member 20 |
| Other gene symbols | KHLHX KLEIP KLHLX RP3-383J4.3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0007010 | Cytoskeleton organization | TAS | biological_process |
| GO:0015629 | Actin cytoskeleton | TAS | cellular_component |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0019964 | Interferon-gamma binding | IDA | molecular_function |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0035455 | Response to interferon-alpha | TAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3354993427 | 0.3314782189 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0541006788 |
| GSE13712_SHEAR | Up | 0.1843217090 |
| GSE13712_STATIC | Up | 0.1137255714 |
| GSE19018 | Down | -0.2988541060 |
| GSE19899_A1 | Down | -0.1229930253 |
| GSE19899_A2 | Up | 0.0166715952 |
| PubMed_21979375_A1 | Down | -0.0481342625 |
| PubMed_21979375_A2 | Down | -0.4772552246 |
| GSE35957 | Up | 0.1534203396 |
| GSE36640 | Up | 0.6589896714 |
| GSE54402 | Down | -0.2394576663 |
| GSE9593 | Down | -0.0264205661 |
| GSE43922 | Down | -0.1126668412 |
| GSE24585 | Up | 0.5054973790 |
| GSE37065 | Down | -0.0253332785 |
| GSE28863_A1 | Up | 0.6097503154 |
| GSE28863_A2 | Up | 0.6445145192 |
| GSE28863_A3 | Down | -0.2038467303 |
| GSE28863_A4 | Down | -0.2306364820 |
| GSE48662 | Down | -0.4193802692 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-429 | MIMAT0001536 | MIRT016632 | Reporter assay | Functional MTI | 20005803 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT020343 | Reporter assay | Functional MTI | 20005803 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT021066 | Reporter assay | Functional MTI | 20005803 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT021655 | Reporter assay | Functional MTI | 20005803 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT024121 | Reporter assay | Functional MTI | 20005803 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-141-3p | MIMAT0000432 | NA | hsa-miR-141 | 20005803 | |||
| hsa-miR-200a-3p | MIMAT0000682 | NA | hsa-miR-200a | 20005803 | |||
| hsa-miR-200b-3p | MIMAT0000318 | NA | hsa-miR-200b | 20005803 | |||
| hsa-miR-429 | MIMAT0001536 | NA | hsa-miR-429 | 20005803 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
