HCSGD entry for GCLC

1. General information

Official gene symbolGCLC
Entrez ID2729
Gene full nameglutamate-cysteine ligase, catalytic subunit
Other gene symbolsGCL GCS GLCL GLCLC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000096Sulfur amino acid metabolic processTASbiological_process
GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0004357Glutamate-cysteine ligase activityIDA IEA IMPmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIBAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0006534Cysteine metabolic processIDAbiological_process
GO:0006536Glutamate metabolic processIDAbiological_process
GO:0006750Glutathione biosynthetic processIDA IEA IMP TASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0006979Response to oxidative stressIDAbiological_process
GO:0008637Apoptotic mitochondrial changesIEAbiological_process
GO:0009408Response to heatIDAbiological_process
GO:0009410Response to xenobiotic stimulusIEAbiological_process
GO:0009725Response to hormoneIDAbiological_process
GO:0016595Glutamate bindingIDAmolecular_function
GO:0017109Glutamate-cysteine ligase complexIEAcellular_component
GO:0019852L-ascorbic acid metabolic processIEAbiological_process
GO:0031397Negative regulation of protein ubiquitinationIEAbiological_process
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043531ADP bindingIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045454Cell redox homeostasisIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0046685Response to arsenic-containing substanceIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0050662Coenzyme bindingIPImolecular_function
GO:0050880Regulation of blood vessel sizeIMPbiological_process
GO:0051409Response to nitrosative stressIEAbiological_process
GO:0051900Regulation of mitochondrial depolarizationIEAbiological_process
GO:1901687Glutathione derivative biosynthetic processTASbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01140029630.85000227950.27015148511.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4672286699
GSE13712_SHEARDown-0.0479279517
GSE13712_STATICDown-0.1450021444
GSE19018Up0.8673266958
GSE19899_A1Up0.3964868188
GSE19899_A2Down-0.0286502955
PubMed_21979375_A1Up0.3230485723
PubMed_21979375_A2Up0.6036631306
GSE35957Up1.0288921195
GSE36640Up0.9139449302
GSE54402Down-0.2349557182
GSE9593Up0.7831224055
GSE43922Up0.8552651540
GSE24585Down-0.2485535496
GSE37065Up0.0093679033
GSE28863_A1Down-0.1393495253
GSE28863_A2Down-0.2819067578
GSE28863_A3Down-0.0520701796
GSE28863_A4Down-0.1297086868
GSE48662Up0.5663496706

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
L-CysteineDB00151 NUTR00018 | DB04443

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT021012ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.