HCSGD entry for RPS6KA6
1. General information
| Official gene symbol | RPS6KA6 |
|---|---|
| Entrez ID | 27330 |
| Gene full name | ribosomal protein S6 kinase, 90kDa, polypeptide 6 |
| Other gene symbols | PP90RSK4 RSK4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | IMP | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007417 | Central nervous system development | TAS | biological_process |
| GO:0045992 | Negative regulation of embryonic development | ISS | biological_process |
| GO:0070373 | Negative regulation of ERK1 and ERK2 cascade | ISS | biological_process |
| GO:2000381 | Negative regulation of mesoderm development | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8331853843 | 0.0881424528 | 0.9999902473 | 0.5631061893 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0223130482 |
| GSE13712_SHEAR | Down | -0.0498914990 |
| GSE13712_STATIC | Up | 0.1557621840 |
| GSE19018 | Down | -0.7422393249 |
| GSE19899_A1 | Down | -0.0240590446 |
| GSE19899_A2 | Down | -0.7913152345 |
| PubMed_21979375_A1 | Down | -0.2273959253 |
| PubMed_21979375_A2 | Down | -0.1774838934 |
| GSE35957 | Down | -0.0578829658 |
| GSE36640 | Up | 0.6028525417 |
| GSE54402 | Down | -0.7492702192 |
| GSE9593 | Up | 0.2210743570 |
| GSE43922 | Down | -0.1346530683 |
| GSE24585 | Up | 0.5058094261 |
| GSE37065 | Down | -0.0110861883 |
| GSE28863_A1 | Down | -0.2410455806 |
| GSE28863_A2 | Up | 0.1518982705 |
| GSE28863_A3 | Down | -0.5478625505 |
| GSE28863_A4 | Down | -0.0215664153 |
| GSE48662 | Up | 0.0162411786 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017599 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029385 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
