HCSGD entry for HTRA2

1. General information

Official gene symbolHTRA2
Entrez ID27429
Gene full nameHtrA serine peptidase 2
Other gene symbolsOMI PARK13 PRSS25
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIMP TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005739MitochondrionIDA IMP TAScellular_component
GO:0005758Mitochondrial intermembrane spaceIDAcellular_component
GO:0005783Endoplasmic reticulumNAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolIDAcellular_component
GO:0006508ProteolysisIMP TASbiological_process
GO:0006672Ceramide metabolic processIEAbiological_process
GO:0007005Mitochondrion organizationIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008233Peptidase activityIDAmolecular_function
GO:0008236Serine-type peptidase activityIDA TASmolecular_function
GO:0009635Response to herbicideIEAbiological_process
GO:0009898Cytoplasmic side of plasma membraneISScellular_component
GO:0010942Positive regulation of cell deathIDAbiological_process
GO:0019742Pentacyclic triterpenoid metabolic processIEAbiological_process
GO:0030900Forebrain developmentIEAbiological_process
GO:0031966Mitochondrial membraneIEAcellular_component
GO:0034605Cellular response to heatIDAbiological_process
GO:0035631CD40 receptor complexISScellular_component
GO:0040014Regulation of multicellular organism growthIEAbiological_process
GO:0043065Positive regulation of apoptotic processIMP TASbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0045786Negative regulation of cell cycleTASbiological_process
GO:0048666Neuron developmentIEAbiological_process
GO:0051082Unfolded protein bindingNASmolecular_function
GO:0060548Negative regulation of cell deathIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIMPbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayIEAbiological_process
GO:0097194Execution phase of apoptosisTASbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02000009500.68484380530.34209407221.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.9999038001
GSE13712_SHEARDown-0.1709272885
GSE13712_STATICDown-0.1923354968
GSE19018Down-0.0008780211
GSE19899_A1Up0.9061216941
GSE19899_A2Up0.9596763787
PubMed_21979375_A1Up1.2804418447
PubMed_21979375_A2Up0.9225005849
GSE35957Down-0.6931916083
GSE36640Up0.4660817429
GSE54402Up0.3449863313
GSE9593Down-0.2068673003
GSE43922Up0.8579694119
GSE24585Up0.0717569198
GSE37065Down-0.0422510195
GSE28863_A1Down-0.4519938942
GSE28863_A2Up0.1320153424
GSE28863_A3Down-0.5234026440
GSE28863_A4Down-0.0924915147
GSE48662Up0.0429601751

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037592CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.