HCSGD entry for SFN

1. General information

Official gene symbolSFN
Entrez ID2810
Gene full namestratifin
Other gene symbolsYWHAS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000079Regulation of cyclin-dependent protein serine/threonine kinase activityIEAbiological_process
GO:0001836Release of cytochrome c from mitochondriaIDAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceTAScellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006469Negative regulation of protein kinase activityTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0008426Protein kinase C inhibitor activityTASmolecular_function
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIDAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030216Keratinocyte differentiationIEAbiological_process
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0030659Cytoplasmic vesicle membraneTAScellular_component
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043616Keratinocyte proliferationIEAbiological_process
GO:0046827Positive regulation of protein export from nucleusIEAbiological_process
GO:0051219Phosphoprotein bindingIEAmolecular_function
GO:0071901Negative regulation of protein serine/threonine kinase activityTASbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:1900740Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02633702370.59945722050.37852478171.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0880555804
GSE13712_SHEARUp1.0172527066
GSE13712_STATICUp0.1855934944
GSE19018Up0.2116958366
GSE19899_A1Up0.1843520222
GSE19899_A2Up0.3585655238
PubMed_21979375_A1Down-0.2383167706
PubMed_21979375_A2Up0.2177051215
GSE35957Down-0.3007954497
GSE36640Down-2.4785391728
GSE54402Down-0.4972370941
GSE9593Down-0.0561473245
GSE43922Down-0.0000390132
GSE24585Up3.9933587872
GSE37065Up0.0433161879
GSE28863_A1Down-0.0785858798
GSE28863_A2Up0.2253320804
GSE28863_A3Up0.1513191878
GSE28863_A4Up0.0027206336
GSE48662Up0.0176500151

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT024082ProteomicsFunctional MTI (Weak)18668040
hsa-miR-34a-5pMIMAT0000255MIRT025569ProteomicsFunctional MTI (Weak)21566225
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23969227Stringent reduction of the extensive proteomic data from this tumor cell model revealed a list of 59 markers including proteins identified in our former studies and a number of novel proteins involved in tumorigenesis and metastasis such as SFN, S100A4, ANXA2, and LGALS1
17657594Interestingly, co-treatment with 20units/ml of SOD, a free radical scavenger, attenuated the synergism elicited by the combinations (2-fold with 25 muM SFN and 20 muM EGCG; and 15-fold with 25 microM SFN and 100 microM EGCG)
17657594Interestingly, co-treatment with 20units/ml of SOD, a free radical scavenger, attenuated the synergism elicited by the combinations (2-fold with 25 muM SFN and 20 muM EGCG; and 15-fold with 25 microM SFN and 100 microM EGCG)
17657594In addition, 20 microM and 100 microM EGCG, but not 25 microM SFN, showed induction of senescence in the HT-29 AP-1 cells subjected to senescence staining
17657594However, both low- and high-dose combinations of SFN and EGCG attenuated the cellular senescence induced by EGCG alone
Entries Per Page
Displaying Page of