HCSGD entry for GPER

1. General information

Official gene symbolGPER
Entrez ID2852
Gene full nameG protein-coupled estrogen receptor 1
Other gene symbolsCEPR CMKRL2 DRY12 FEG-1 GPCR-Br GPR30 LERGU LERGU2 LyGPR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0001934Positive regulation of protein phosphorylationIDA ISSbiological_process
GO:0001956Positive regulation of neurotransmitter secretionISSbiological_process
GO:0002695Negative regulation of leukocyte activationIDAbiological_process
GO:0003682Chromatin bindingIDAmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005496Steroid bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularISScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005635Nuclear envelopeIDAcellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEA ISSbiological_process
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0008285Negative regulation of cell proliferationISSbiological_process
GO:0010579Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0010628Positive regulation of gene expressionISSbiological_process
GO:0010629Negative regulation of gene expressionISSbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0014069Postsynaptic densityISScellular_component
GO:0017082Mineralocorticoid receptor activityISSmolecular_function
GO:0019228Neuronal action potentialISSbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030263Apoptotic chromosome condensationISSbiological_process
GO:0030264Nuclear fragmentation involved in apoptotic nuclear changeISSbiological_process
GO:0030284Estrogen receptor activityIDAmolecular_function
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0030424AxonISScellular_component
GO:0030425DendriteISScellular_component
GO:0030518Intracellular steroid hormone receptor signaling pathwayIDAbiological_process
GO:0030659Cytoplasmic vesicle membraneIDAcellular_component
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0031959Mineralocorticoid receptor signaling pathwayISSbiological_process
GO:0031966Mitochondrial membraneISScellular_component
GO:0032024Positive regulation of insulin secretionIEA ISSbiological_process
GO:0032591Dendritic spine membraneISScellular_component
GO:0032962Positive regulation of inositol trisphosphate biosynthetic processIDAbiological_process
GO:0042734Presynaptic membraneISScellular_component
GO:0043065Positive regulation of apoptotic processISSbiological_process
GO:0043198Dendritic shaftISScellular_component
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processISSbiological_process
GO:0043401Steroid hormone mediated signaling pathwayIDA ISSbiological_process
GO:0043410Positive regulation of MAPK cascadeISSbiological_process
GO:0043679Axon terminusISScellular_component
GO:0044327Dendritic spine headISScellular_component
GO:0045087Innate immune responseIEAbiological_process
GO:0045095Keratin filamentIDAcellular_component
GO:0045599Negative regulation of fat cell differentiationISSbiological_process
GO:0045742Positive regulation of epidermal growth factor receptor signaling pathwayIDAbiological_process
GO:0045745Positive regulation of G-protein coupled receptor protein signaling pathwayIDAbiological_process
GO:0045909Positive regulation of vasodilationISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEA ISSbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048786Presynaptic active zoneISScellular_component
GO:0050728Negative regulation of inflammatory responseIDAbiological_process
GO:0050769Positive regulation of neurogenesisIEA ISSbiological_process
GO:0051053Negative regulation of DNA metabolic processISSbiological_process
GO:0051055Negative regulation of lipid biosynthetic processISSbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIDAbiological_process
GO:0051480Cytosolic calcium ion homeostasisISSbiological_process
GO:0055037Recycling endosomeIDAcellular_component
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDA ISSbiological_process
GO:0070474Positive regulation of uterine smooth muscle contractionIDAbiological_process
GO:0071157Negative regulation of cell cycle arrestISSbiological_process
GO:0071333Cellular response to glucose stimulusIEA ISSbiological_process
GO:0071356Cellular response to tumor necrosis factorIDAbiological_process
GO:0071375Cellular response to peptide hormone stimulusIDAbiological_process
GO:0071389Cellular response to mineralocorticoid stimulusISSbiological_process
GO:0071392Cellular response to estradiol stimulusIDAbiological_process
GO:0090004Positive regulation of establishment of protein localization to plasma membraneIDAbiological_process
GO:0090200Positive regulation of release of cytochrome c from mitochondriaISSbiological_process
GO:0097481Neuronal postsynaptic densityISScellular_component
GO:2000353Positive regulation of endothelial cell apoptotic processISSbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22366565860.53795388850.90402897931.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0713803583
GSE13712_SHEARDown-1.1191247285
GSE13712_STATICDown-0.3299000200
GSE19018Up0.1003737249
GSE19899_A1Up0.0471864831
GSE19899_A2Up0.0620341241
PubMed_21979375_A1Up0.3085879711
PubMed_21979375_A2Up0.3545044040
GSE35957Down-0.1205071761
GSE36640Up0.3767877531
GSE54402Down-0.1384277186
GSE9593Up0.2294093731
GSE43922Up0.2204755760
GSE24585Up0.5055162957
GSE37065Down-0.2456258336
GSE28863_A1Down-0.2217425337
GSE28863_A2Up0.5163379172
GSE28863_A3Up0.1003336130
GSE28863_A4Down-0.1015914495
GSE48662Down-0.0387023047

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019084MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.