HCSGD entry for GPT

1. General information

Official gene symbolGPT
Entrez ID2875
Gene full nameglutamic-pyruvate transaminase (alanine aminotransferase)
Other gene symbolsAAT1 ALT1 GPT1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004021L-alanine:2-oxoglutarate aminotransferase activityEXP NASmolecular_function
GO:0005829CytosolTAScellular_component
GO:0008652Cellular amino acid biosynthetic processTASbiological_process
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042853L-alanine catabolic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28625140760.86266453780.98571367091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1127636239
GSE13712_SHEARUp0.2697819341
GSE13712_STATICDown-0.0182245874
GSE19018Up0.1603031298
GSE19899_A1Up0.1268254666
GSE19899_A2Up0.0330282275
PubMed_21979375_A1Up0.0181502227
PubMed_21979375_A2Down-0.3279539854
GSE35957Up0.3059221014
GSE36640Up0.1789475743
GSE54402Down-0.0581904406
GSE9593Up0.0557410415
GSE43922Up0.0455577602
GSE24585Down-0.0548297033
GSE37065Up0.1350787928
GSE28863_A1Down-0.1691843516
GSE28863_A2Up0.0364434954
GSE28863_A3Up0.4905543864
GSE28863_A4Up0.1120956144
GSE48662Up0.0351164182

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
L-AlanineDB00160 NUTR00013
PhenelzineDB00780 APRD00099

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17295869We assessed clinicopathological parameters that reflect cell-cycle turnover, including Ki-67 positive index, serum alanine aminotransferase (ALT) level and degree of fibrosis, and also oxidative stress-related parameters, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG) expression
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