HCSGD entry for MED4
1. General information
| Official gene symbol | MED4 |
|---|---|
| Entrez ID | 29079 |
| Gene full name | mediator complex subunit 4 |
| Other gene symbols | ARC36 DRIP36 HSPC126 TRAP36 VDRIP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001104 | RNA polymerase II transcription cofactor activity | IDA IEA | molecular_function |
| GO:0003712 | Transcription cofactor activity | IDA | molecular_function |
| GO:0004872 | Receptor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | IDA TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016592 | Mediator complex | IDA IEA | cellular_component |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | NAS | molecular_function |
| GO:0030518 | Intracellular steroid hormone receptor signaling pathway | IDA | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | IDA | biological_process |
| GO:0042809 | Vitamin D receptor binding | NAS | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0046966 | Thyroid hormone receptor binding | IDA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9919440219 | 0.0149559515 | 0.9999902473 | 0.2409152999 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1722746516 |
| GSE13712_SHEAR | Down | -0.3063944569 |
| GSE13712_STATIC | Down | -0.1959200096 |
| GSE19018 | Down | -0.4714579282 |
| GSE19899_A1 | Down | -0.2605935668 |
| GSE19899_A2 | Down | -0.3838189905 |
| PubMed_21979375_A1 | Down | -0.5303863199 |
| PubMed_21979375_A2 | Down | -0.7442296231 |
| GSE35957 | Down | -0.2792494191 |
| GSE36640 | Down | -0.6704993336 |
| GSE54402 | Down | -0.1426650413 |
| GSE9593 | Down | -0.1840974917 |
| GSE43922 | Down | -0.3087745425 |
| GSE24585 | Down | -0.2043345002 |
| GSE37065 | Up | 0.1899473396 |
| GSE28863_A1 | Up | 0.1829826366 |
| GSE28863_A2 | Down | -0.0861835181 |
| GSE28863_A3 | Down | -0.1582162064 |
| GSE28863_A4 | Up | 0.0527256064 |
| GSE48662 | Down | -0.4955627819 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-425-5p | MIMAT0003393 | MIRT016676 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021128 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT023475 | Sequencing | Functional MTI (Weak) | 20371350 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
