HCSGD entry for GSS

1. General information

Official gene symbolGSS
Entrez ID2937
Gene full nameglutathione synthetase
Other gene symbolsGSHS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0004363Glutathione synthase activityIEA TASmolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006520Cellular amino acid metabolic processTASbiological_process
GO:0006750Glutathione biosynthetic processTASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0006979Response to oxidative stressTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0009410Response to xenobiotic stimulusIEAbiological_process
GO:0016594Glycine bindingIEAmolecular_function
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0034612Response to tumor necrosis factorIEAbiological_process
GO:0042277Peptide bindingIEAmolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043200Response to amino acidIEAbiological_process
GO:0043295Glutathione bindingIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046686Response to cadmium ionIEAbiological_process
GO:1901687Glutathione derivative biosynthetic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04643098670.90297268720.47780316411.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3563167624
GSE13712_SHEARUp0.1558602801
GSE13712_STATICUp0.1203583005
GSE19018Up0.1795837467
GSE19899_A1Up0.1624105637
GSE19899_A2Up0.7998538638
PubMed_21979375_A1Down-0.0704334941
PubMed_21979375_A2Up0.5565546809
GSE35957Up0.0452488085
GSE36640Up0.5132007957
GSE54402Up0.2159225394
GSE9593Up0.1007785114
GSE43922Up0.1725902458
GSE24585Up0.5337282787
GSE37065Down-0.0526158835
GSE28863_A1Down-0.1792695748
GSE28863_A2Down-0.2646864033
GSE28863_A3Down-0.7275226853
GSE28863_A4Up0.1552424112
GSE48662Up0.0885820471

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GlutathioneDB00143 NUTR00029 | EXPT01650
GlycineDB00145 NUTR00028
L-CysteineDB00151 NUTR00018 | DB04443
gamma-GlutamylcysteineDB03408 EXPT00168
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92b-3pMIMAT0003218MIRT040592CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041404CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043308CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

2327400177 (nmol/min/mg protein) and upregulated the gene expression levels of copper transport protein ATOX1, glutathione synthetase (GSS) and thioredoxin reductase 1 (TXNRD1) while down-regulated aldehyde oxidase 1 (AOX1)
2327400177 (nmol/min/mg protein) and upregulated the gene expression levels of copper transport protein ATOX1, glutathione synthetase (GSS) and thioredoxin reductase 1 (TXNRD1) while down-regulated aldehyde oxidase 1 (AOX1)
16820894Growth of A549 cells in the presence of buthionine sulfoximine, an inhibitor of glutathione synthetase, amplified the level of constitutive H2AX phosphorylation in A549 cells
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